N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN SYSTEMIC SCLEROSIS PATIENTS: CORRELATION WITH NAILFOLD CAPILLAROSCOPY FINDINGS
Background. Pulmonary arterial hypertension (PAH) is an important cause of morbidity and mortality in patients with systemic sclerosis (SSc). This condition is diagnosed by cardiac Doppler ultrasonography, right-heart catheterization, or by serum levels of N-terminal pro-brain natriuretic peptide (...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2019-03-01
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| Series: | Romanian Journal of Rheumatology |
| Subjects: | |
| Online Access: | https://revistemedicale.amaltea.ro/Romanian_Journal_of_RHEUMATOLOGY/Revista_Romana_de_REUMATOLOGIE-2019-Nr.1/RJR_2019_1_Art-05.pdf |
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| author | Alexandru Caraba Andreea Munteanu Daniela Jianu Diana Nicoara Flavia Corina Babalic Dinu Valentin Balanescu Denisa Predeteanu |
| author_facet | Alexandru Caraba Andreea Munteanu Daniela Jianu Diana Nicoara Flavia Corina Babalic Dinu Valentin Balanescu Denisa Predeteanu |
| author_sort | Alexandru Caraba |
| collection | DOAJ |
| description | Background. Pulmonary arterial hypertension (PAH) is an important cause of morbidity and mortality in patients
with systemic sclerosis (SSc). This condition is diagnosed by cardiac Doppler ultrasonography, right-heart catheterization, or by serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP). The aim of this study was to assess the association between serum NT-proBNP and nailfold capillaroscopic patterns in SSc patients. We also analyzed the association between pulmonary function parameters, NT-proBNP, and nailfold capillary findings in patients diagnosed with SSc and PAH.
Material and methods. We retrospectively analyzed SSc patients and healthy controls from our institution between July 2016 - December 2018. We assessed by chart review: pulmonary artery systolic pressure (PASP),
forced vital capacity (FVC), forced expiratory volume in 1 sec/forced vital capacity ratio (FEV1/FVC ratio), the
number of nailfold capillaries/mm and NT-proBNP. Statistical analyses were performed using the Student’s t-test, ANOVA test and the Pearson’s correlation.
Results. Seventeen patients with SSc and 17 healthy controls matched for age and gender were included. Among SSc patients, 13 had diffuse cutaneous SSc (dcSSc) and 4 patients had limited cutaneous SSc (lcSSc). PAH was identified in 10 SSc patients. In SSc patients, significant correlations have been identified between PASP and NT-proBNP (r=0.9, p<0.0001), nailfold capillaries density and PASP (r=-0.95, p<0.0001), and nailfold capillaries density and NT-proBNP (r=-0.84, p<0.0001).
Conclusion. We suggest that in patients with SSc, NT-proBNP is significantly correlated with PASP and nailfold
capillaroscopic findings. |
| first_indexed | 2024-12-13T19:13:38Z |
| format | Article |
| id | doaj.art-6b15e8ec05a04d35a4db6d68d8942c21 |
| institution | Directory Open Access Journal |
| issn | 1843-0791 2069-6086 |
| language | English |
| last_indexed | 2024-12-13T19:13:38Z |
| publishDate | 2019-03-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Rheumatology |
| spelling | doaj.art-6b15e8ec05a04d35a4db6d68d8942c212022-12-21T23:34:20ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862019-03-01281232910.37897/RJR.2019.1.5N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN SYSTEMIC SCLEROSIS PATIENTS: CORRELATION WITH NAILFOLD CAPILLAROSCOPY FINDINGSAlexandru Caraba0Andreea Munteanu1Daniela Jianu2Diana Nicoara3Flavia Corina Babalic4Dinu Valentin Balanescu5Denisa Predeteanu6Department of Internal Medicine, Division of Rheumatology, Victor Babes University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Internal Medicine, Division of Rheumatology, Victor Babes University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Medical Semiology, Victor Babes University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Medical Semiology, Victor Babes University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Internal Medicine, Division of Rheumatology, Victor Babes University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Internal Medicine and Rheumatology, Sfanta Maria Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Internal Medicine and Rheumatology, Sfanta Maria Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaBackground. Pulmonary arterial hypertension (PAH) is an important cause of morbidity and mortality in patients with systemic sclerosis (SSc). This condition is diagnosed by cardiac Doppler ultrasonography, right-heart catheterization, or by serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP). The aim of this study was to assess the association between serum NT-proBNP and nailfold capillaroscopic patterns in SSc patients. We also analyzed the association between pulmonary function parameters, NT-proBNP, and nailfold capillary findings in patients diagnosed with SSc and PAH. Material and methods. We retrospectively analyzed SSc patients and healthy controls from our institution between July 2016 - December 2018. We assessed by chart review: pulmonary artery systolic pressure (PASP), forced vital capacity (FVC), forced expiratory volume in 1 sec/forced vital capacity ratio (FEV1/FVC ratio), the number of nailfold capillaries/mm and NT-proBNP. Statistical analyses were performed using the Student’s t-test, ANOVA test and the Pearson’s correlation. Results. Seventeen patients with SSc and 17 healthy controls matched for age and gender were included. Among SSc patients, 13 had diffuse cutaneous SSc (dcSSc) and 4 patients had limited cutaneous SSc (lcSSc). PAH was identified in 10 SSc patients. In SSc patients, significant correlations have been identified between PASP and NT-proBNP (r=0.9, p<0.0001), nailfold capillaries density and PASP (r=-0.95, p<0.0001), and nailfold capillaries density and NT-proBNP (r=-0.84, p<0.0001). Conclusion. We suggest that in patients with SSc, NT-proBNP is significantly correlated with PASP and nailfold capillaroscopic findings.https://revistemedicale.amaltea.ro/Romanian_Journal_of_RHEUMATOLOGY/Revista_Romana_de_REUMATOLOGIE-2019-Nr.1/RJR_2019_1_Art-05.pdfnailfold capillaroscopynt-probnppulmonary hypertensionsystemic sclerosis |
| spellingShingle | Alexandru Caraba Andreea Munteanu Daniela Jianu Diana Nicoara Flavia Corina Babalic Dinu Valentin Balanescu Denisa Predeteanu N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN SYSTEMIC SCLEROSIS PATIENTS: CORRELATION WITH NAILFOLD CAPILLAROSCOPY FINDINGS Romanian Journal of Rheumatology nailfold capillaroscopy nt-probnp pulmonary hypertension systemic sclerosis |
| title | N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN SYSTEMIC SCLEROSIS PATIENTS: CORRELATION WITH NAILFOLD CAPILLAROSCOPY FINDINGS |
| title_full | N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN SYSTEMIC SCLEROSIS PATIENTS: CORRELATION WITH NAILFOLD CAPILLAROSCOPY FINDINGS |
| title_fullStr | N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN SYSTEMIC SCLEROSIS PATIENTS: CORRELATION WITH NAILFOLD CAPILLAROSCOPY FINDINGS |
| title_full_unstemmed | N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN SYSTEMIC SCLEROSIS PATIENTS: CORRELATION WITH NAILFOLD CAPILLAROSCOPY FINDINGS |
| title_short | N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE IN SYSTEMIC SCLEROSIS PATIENTS: CORRELATION WITH NAILFOLD CAPILLAROSCOPY FINDINGS |
| title_sort | n terminal pro brain natriuretic peptide in systemic sclerosis patients correlation with nailfold capillaroscopy findings |
| topic | nailfold capillaroscopy nt-probnp pulmonary hypertension systemic sclerosis |
| url | https://revistemedicale.amaltea.ro/Romanian_Journal_of_RHEUMATOLOGY/Revista_Romana_de_REUMATOLOGIE-2019-Nr.1/RJR_2019_1_Art-05.pdf |
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