Gestational age, birth weight, and blood culture microbial patterns in late-onset neonatal sepsis
Background The three main causes of neonatal deaths in Indonesia according to the WHO are sepsis, prematurity, and asphyxia. A suboptimal hospital environment increases the risk of late-onset neonatal sepsis (LONS), which in turn can prolong hospital stays. Objective To assess for possible assoc...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2024-02-01
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| Series: | Paediatrica Indonesiana |
| Subjects: | |
| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/3258 |
| _version_ | 1827319141577523200 |
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| author | Muhammad Ramadhika Stephen Diah Iskandar Ivana Yapiy Yurika Elizabeth Susanti Marcella Amadea Wijaya Rinawati Rohsiswatmo |
| author_facet | Muhammad Ramadhika Stephen Diah Iskandar Ivana Yapiy Yurika Elizabeth Susanti Marcella Amadea Wijaya Rinawati Rohsiswatmo |
| author_sort | Muhammad Ramadhika |
| collection | DOAJ |
| description | Background The three main causes of neonatal deaths in Indonesia according to the WHO are sepsis, prematurity, and asphyxia. A suboptimal hospital environment increases the risk of late-onset neonatal sepsis (LONS), which in turn can prolong hospital stays.
Objective To assess for possible associations of bacterial patterns in neonates with LONS, prematurity, and/or low birth weight.
Methods Medical record data of 1,706 hospitalized neonates who were treated for sepsis or other disease in the Neonatal Unit, Dr. Cipto Mangunkusumo Hospital (CMH), Jakarta in 2020 were analyzed retrospectively. A total of 262 neonates had proven LONS. We assessed for possible risk factors such as gestational age, birth weight, and cultured blood microbes.
Results Out of a total of 1,706 neonates admitted to the neonatal unit, the incidence of proven LONS was 15.4%. LONS was more prevalent (58.4%) in preterm than in full-term (41.6%) neonates. The majority (67.6%) of subjects with proven LONS were neonates with low birth weight (LBW) (<2,500 grams), and the largest percentage of them (35.1%) was in the 1,500-2,500-gram group. Gram negative bacteria emerged as the predominant pathogens of LONS patients in our hospital; the most common were Klebsiella pneumonia, Acinetobacter spp., Escherichia coli, Enterobacter spp., and Pseudomonas aeruginosa.
Conclusion The proportion of LONS among LBW and preterm neonates is significantly higher compared to normal birth weight and neonates. In our unit, LONS was mostly caused by Gram-negative bacteria. The antibiotic susceptibility of the various pathogens causing LONS in CMH should be tested and compared to the current empirical antibiotic guidelines used in CMH. |
| first_indexed | 2024-04-25T00:14:32Z |
| format | Article |
| id | doaj.art-6b163a730df04852ba256cf014b15ed4 |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-04-25T00:14:32Z |
| publishDate | 2024-02-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-6b163a730df04852ba256cf014b15ed42024-03-13T05:20:45ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2024-02-0164151810.14238/pi64.1.2024.51-83258Gestational age, birth weight, and blood culture microbial patterns in late-onset neonatal sepsisMuhammad Ramadhika0Stephen Diah Iskandar1Ivana Yapiy2Yurika Elizabeth Susanti3Marcella Amadea Wijaya4Rinawati Rohsiswatmo5Faculty of Medicine, Universitas Indonesia, JakartaFaculty of Medicine, Universitas Indonesia, JakartaFaculty of Medicine, Universitas Indonesia, JakartaFaculty of Medicine, Atma Jaya Catholic University of Indonesia, JakartaFaculty of Medicine, Atma Jaya Catholic University of Indonesia, JakartaDepartment of Child Health, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, JakartaBackground The three main causes of neonatal deaths in Indonesia according to the WHO are sepsis, prematurity, and asphyxia. A suboptimal hospital environment increases the risk of late-onset neonatal sepsis (LONS), which in turn can prolong hospital stays. Objective To assess for possible associations of bacterial patterns in neonates with LONS, prematurity, and/or low birth weight. Methods Medical record data of 1,706 hospitalized neonates who were treated for sepsis or other disease in the Neonatal Unit, Dr. Cipto Mangunkusumo Hospital (CMH), Jakarta in 2020 were analyzed retrospectively. A total of 262 neonates had proven LONS. We assessed for possible risk factors such as gestational age, birth weight, and cultured blood microbes. Results Out of a total of 1,706 neonates admitted to the neonatal unit, the incidence of proven LONS was 15.4%. LONS was more prevalent (58.4%) in preterm than in full-term (41.6%) neonates. The majority (67.6%) of subjects with proven LONS were neonates with low birth weight (LBW) (<2,500 grams), and the largest percentage of them (35.1%) was in the 1,500-2,500-gram group. Gram negative bacteria emerged as the predominant pathogens of LONS patients in our hospital; the most common were Klebsiella pneumonia, Acinetobacter spp., Escherichia coli, Enterobacter spp., and Pseudomonas aeruginosa. Conclusion The proportion of LONS among LBW and preterm neonates is significantly higher compared to normal birth weight and neonates. In our unit, LONS was mostly caused by Gram-negative bacteria. The antibiotic susceptibility of the various pathogens causing LONS in CMH should be tested and compared to the current empirical antibiotic guidelines used in CMH.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/3258late onset neonatal sepsisgestational agebirth weightmicrobial pattern |
| spellingShingle | Muhammad Ramadhika Stephen Diah Iskandar Ivana Yapiy Yurika Elizabeth Susanti Marcella Amadea Wijaya Rinawati Rohsiswatmo Gestational age, birth weight, and blood culture microbial patterns in late-onset neonatal sepsis Paediatrica Indonesiana late onset neonatal sepsis gestational age birth weight microbial pattern |
| title | Gestational age, birth weight, and blood culture microbial patterns in late-onset neonatal sepsis |
| title_full | Gestational age, birth weight, and blood culture microbial patterns in late-onset neonatal sepsis |
| title_fullStr | Gestational age, birth weight, and blood culture microbial patterns in late-onset neonatal sepsis |
| title_full_unstemmed | Gestational age, birth weight, and blood culture microbial patterns in late-onset neonatal sepsis |
| title_short | Gestational age, birth weight, and blood culture microbial patterns in late-onset neonatal sepsis |
| title_sort | gestational age birth weight and blood culture microbial patterns in late onset neonatal sepsis |
| topic | late onset neonatal sepsis gestational age birth weight microbial pattern |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/3258 |
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