Implicating calpain in tau-mediated toxicity in vivo.

Implicating calpain in tau-mediated toxicity in vivo.

Alzheimer's disease and other related neurodegenerative disorders known as tauopathies are characterized by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. Several laboratories have identified a 17 kD proteolytic fragment of tau in d...

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Bibliographic Details
Main Authors:	James B Reinecke, Sarah L DeVos, James P McGrath, Amanda M Shepard, Dustin K Goncharoff, Don N Tait, Samantha R Fleming, Michael P Vincent, Michelle L Steinhilb
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3157467?pdf=render

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