Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial
Background: Huanglian-jie-du (HJD) granule, which is composed of representative “heat-clearing” herbs has been used for Hwa-byung. Hwa-byung is a culture-bound syndrome in Korea, characterized by distinct somatic symptoms such as chest congestion and heat sensation resulting from suppressed anger. W...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422020300858 |
| _version_ | 1818848354255241216 |
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| author | Yujin Choi Yunna Kim Ojin Kwon Sun-Yong Chung Seung-Hun Cho |
| author_facet | Yujin Choi Yunna Kim Ojin Kwon Sun-Yong Chung Seung-Hun Cho |
| author_sort | Yujin Choi |
| collection | DOAJ |
| description | Background: Huanglian-jie-du (HJD) granule, which is composed of representative “heat-clearing” herbs has been used for Hwa-byung. Hwa-byung is a culture-bound syndrome in Korea, characterized by distinct somatic symptoms such as chest congestion and heat sensation resulting from suppressed anger. We investigated the effect of HJD in patients with Hwa-byung. Methods: Forty-four patients with Hwa-byung were recruited, and HJD or placebo granules were administered orally three times daily for seven days. The two primary outcomes were somatic symptoms, which were measured by Patient Health Questionnaire of physical symptoms (PHQ-15), and insomnia, which was measured by Insomnia Severity Index (ISI) at post-treatment. Results: Between July 10 and October 31, 2017, 44 patients with Hwa-byung (mean age 36.68 years; and 38 female) were randomly assigned to HJD (n = 22) or placebo (n = 22) group. After administration of HJD or placebo granule for seven days, ISI score was lower in the HJD group compared to placebo group at post-treatment (adjusted mean difference -2.56 [95% CI -4.72 to -0.39], p = 0.0208). Meanwhile, there was no difference in PHQ-15 score between HJD group and placebo group at post-treatment (adjusted mean difference -0.50 [95% CI: -3.02–4.02], p = 0.7812). Conclusions: Our results suggest that the administration of HJD granule has a potential to improve insomnia in Hwa-byung patients. Effect of HJD granule for general somatic symptoms in Hwa-byung patients is unclear, and further researches are needed. Trial registration: Clinical Research Information Service, KCT0002379. |
| first_indexed | 2024-12-19T06:16:00Z |
| format | Article |
| id | doaj.art-6b1c0e126ae04f83b4b5690f3533768d |
| institution | Directory Open Access Journal |
| issn | 2213-4220 |
| language | English |
| last_indexed | 2024-12-19T06:16:00Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj.art-6b1c0e126ae04f83b4b5690f3533768d2022-12-21T20:32:51ZengElsevierIntegrative Medicine Research2213-42202021-06-01102100453Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trialYujin Choi0Yunna Kim1Ojin Kwon2Sun-Yong Chung3Seung-Hun Cho4Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaDepartment of Neuropsychiatry, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaDepartment of Neuropsychiatry, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Neuropsychiatry, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea; Corresponding author at: Kyung Hee University Medical Center, Kyung Hee University, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.Background: Huanglian-jie-du (HJD) granule, which is composed of representative “heat-clearing” herbs has been used for Hwa-byung. Hwa-byung is a culture-bound syndrome in Korea, characterized by distinct somatic symptoms such as chest congestion and heat sensation resulting from suppressed anger. We investigated the effect of HJD in patients with Hwa-byung. Methods: Forty-four patients with Hwa-byung were recruited, and HJD or placebo granules were administered orally three times daily for seven days. The two primary outcomes were somatic symptoms, which were measured by Patient Health Questionnaire of physical symptoms (PHQ-15), and insomnia, which was measured by Insomnia Severity Index (ISI) at post-treatment. Results: Between July 10 and October 31, 2017, 44 patients with Hwa-byung (mean age 36.68 years; and 38 female) were randomly assigned to HJD (n = 22) or placebo (n = 22) group. After administration of HJD or placebo granule for seven days, ISI score was lower in the HJD group compared to placebo group at post-treatment (adjusted mean difference -2.56 [95% CI -4.72 to -0.39], p = 0.0208). Meanwhile, there was no difference in PHQ-15 score between HJD group and placebo group at post-treatment (adjusted mean difference -0.50 [95% CI: -3.02–4.02], p = 0.7812). Conclusions: Our results suggest that the administration of HJD granule has a potential to improve insomnia in Hwa-byung patients. Effect of HJD granule for general somatic symptoms in Hwa-byung patients is unclear, and further researches are needed. Trial registration: Clinical Research Information Service, KCT0002379.http://www.sciencedirect.com/science/article/pii/S2213422020300858AngerCultural psychiatryHuanglian-jie-du granuleHwa-byungInsomnia |
| spellingShingle | Yujin Choi Yunna Kim Ojin Kwon Sun-Yong Chung Seung-Hun Cho Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial Integrative Medicine Research Anger Cultural psychiatry Huanglian-jie-du granule Hwa-byung Insomnia |
| title | Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial |
| title_full | Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial |
| title_fullStr | Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial |
| title_full_unstemmed | Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial |
| title_short | Effect of herbal medicine (Huanglian-jie-du granule) for somatic symptoms and insomnia in patients with Hwa-byung: A randomized controlled trial |
| title_sort | effect of herbal medicine huanglian jie du granule for somatic symptoms and insomnia in patients with hwa byung a randomized controlled trial |
| topic | Anger Cultural psychiatry Huanglian-jie-du granule Hwa-byung Insomnia |
| url | http://www.sciencedirect.com/science/article/pii/S2213422020300858 |
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