Penilloic acid is the chief culprit involved in non-IgE mediated, immediate penicillin-induced hypersensitivity reactions in mice

Penilloic acid is the chief culprit involved in non-IgE mediated, immediate penicillin-induced hypersensitivity reactions in mice

Metabolites/impurities (MIs) of penicillin are normally considered to be the main substances inducing immediate hypersensitivity reactions in penicillin treatment. Our previous research found that penicillin can cause non-allergic hypersensitivity reactions (NAHRs) by directly triggering vascular hy...

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Bibliographic Details
Main Authors:	Dunfang Wang, Jiayin Han, Chen Pan, Chunying Li, Yong Zhao, Suyan Liu, Yushi Zhang, Jingzhuo Tian, Yan Yi, Jingjing Zhu, Chenyue Liu, Yuan Wang, Zhong Xian, Jing Meng, Shasha Qin, Xuan Tang, Fang Wang, Aihua Liang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Pharmacology
Subjects:	penilloic acid penicillin vascular leakage arachidonic acid non-allergic hypersensitivity reactions RhoA/ROCK signaling pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.874486/full

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