Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems
Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch and pruritus anywhere on the body for more than 6 weeks. Although basophil- and mast cell-released inflammatory mediators, such as histamine, play important r...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10320 |
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| author | Yuhki Yanase Daiki Matsubara Shunsuke Takahagi Akio Tanaka Koichiro Ozawa Michihiro Hide |
| author_facet | Yuhki Yanase Daiki Matsubara Shunsuke Takahagi Akio Tanaka Koichiro Ozawa Michihiro Hide |
| author_sort | Yuhki Yanase |
| collection | DOAJ |
| description | Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch and pruritus anywhere on the body for more than 6 weeks. Although basophil- and mast cell-released inflammatory mediators, such as histamine, play important roles in the pathogenesis of CSU, the detailed underlying mechanism is not clear. Since several auto-antibodies, IgGs which recognize IgE or the high-affinity IgE receptor (FcεRI) and IgEs against other self-antigens, are detected in CSU patients, they are considered to activate both mast cells in the skin and basophils circulating in the blood. In addition, we and other groups demonstrated that the coagulation and complement system also contribute to the development of urticaria. Here, we summarized the behaviors, markers and targets of basophils in relation to the coagulation–complement system, and for the treatment of CSU. |
| first_indexed | 2024-03-11T02:20:23Z |
| format | Article |
| id | doaj.art-6b1e3a339f3e4c6f9d0623dc804f4370 |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:20:23Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6b1e3a339f3e4c6f9d0623dc804f43702023-11-18T10:51:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121032010.3390/ijms241210320Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement SystemsYuhki Yanase0Daiki Matsubara1Shunsuke Takahagi2Akio Tanaka3Koichiro Ozawa4Michihiro Hide5Department of Pharmacotherapy, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, JapanDepartment of Dermatology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, JapanDepartment of Dermatology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, JapanDepartment of Dermatology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, JapanDepartment of Pharmacotherapy, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, JapanDepartment of Dermatology, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-0046, JapanChronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch and pruritus anywhere on the body for more than 6 weeks. Although basophil- and mast cell-released inflammatory mediators, such as histamine, play important roles in the pathogenesis of CSU, the detailed underlying mechanism is not clear. Since several auto-antibodies, IgGs which recognize IgE or the high-affinity IgE receptor (FcεRI) and IgEs against other self-antigens, are detected in CSU patients, they are considered to activate both mast cells in the skin and basophils circulating in the blood. In addition, we and other groups demonstrated that the coagulation and complement system also contribute to the development of urticaria. Here, we summarized the behaviors, markers and targets of basophils in relation to the coagulation–complement system, and for the treatment of CSU.https://www.mdpi.com/1422-0067/24/12/10320chronic spontaneous urticaria (CSU)basophilmast cellhistaminebiomarkercoagulation |
| spellingShingle | Yuhki Yanase Daiki Matsubara Shunsuke Takahagi Akio Tanaka Koichiro Ozawa Michihiro Hide Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems International Journal of Molecular Sciences chronic spontaneous urticaria (CSU) basophil mast cell histamine biomarker coagulation |
| title | Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems |
| title_full | Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems |
| title_fullStr | Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems |
| title_full_unstemmed | Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems |
| title_short | Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems |
| title_sort | basophil characteristics as a marker of the pathogenesis of chronic spontaneous urticaria in relation to the coagulation and complement systems |
| topic | chronic spontaneous urticaria (CSU) basophil mast cell histamine biomarker coagulation |
| url | https://www.mdpi.com/1422-0067/24/12/10320 |
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