Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome.

Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome.

The streptothricin natural product mixture (also known as nourseothricin) was discovered in the early 1940s, generating intense initial interest because of excellent gram-negative activity. Here, we establish the activity spectrum of nourseothricin and its main components, streptothricin F (S-F, 1 l...

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Bibliographic Details
Main Authors: Christopher E Morgan, Yoon-Suk Kang, Alex B Green, Kenneth P Smith, Matthew G Dowgiallo, Brandon C Miller, Lucius Chiaraviglio, Katherine A Truelson, Katelyn E Zulauf, Shade Rodriguez, Anthony D Kang, Roman Manetsch, Edward W Yu, James E Kirby
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002091

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