Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study
Abstract In a nationwide prospective cohort of Korean infants with very low birthweights (VLBW, birth weight < 1500 g) from 70 neonatal intensive care units of the Korean Neonatal Network, we investigated neurodevelopmental outcomes in preterm infants with retinopathy of prematurity (ROP) from 21...
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| Format: | Article |
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Nature Portfolio
2022-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-09053-8 |
| _version_ | 1828313476797300736 |
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| author | Ja-Hye Ahn Kyeong Mi Lee Mi Jung Kim Hyun-Kyung Park Yu Jeong Kim Seong Joon Ahn Hyun Ju Lee |
| author_facet | Ja-Hye Ahn Kyeong Mi Lee Mi Jung Kim Hyun-Kyung Park Yu Jeong Kim Seong Joon Ahn Hyun Ju Lee |
| author_sort | Ja-Hye Ahn |
| collection | DOAJ |
| description | Abstract In a nationwide prospective cohort of Korean infants with very low birthweights (VLBW, birth weight < 1500 g) from 70 neonatal intensive care units of the Korean Neonatal Network, we investigated neurodevelopmental outcomes in preterm infants with retinopathy of prematurity (ROP) from 2132 infants with VLBW who had undergone developmental assessments at 18–24 months of corrected age. Motor, cognitive, or language delay was determined using developmental scores that were less than 1 standard deviation from the average. Comparative analyses and multivariate regression analyses were performed to validate the association between ROP or its treatment and developmental delay. Motor (52.8% vs. 36.3%), cognitive (46.8% vs. 31.6%), and language delays (42.5% vs. 28.4%) were noted more frequently in infants with ROP than in those without ROP; this was statistically significant (all P < 0.001). Multivariate analyses showed that motor and cognitive delays were significantly associated with ROP. There were no remarkable differences between the neurodevelopmental outcomes and the treatment modalities (laser photocoagulation, anti-vascular endothelial growth factor injection, or both) for ROP, and both stratification and multivariate regression analyses confirmed no significant association between anti-vascular endothelial growth factor therapy and neurodevelopmental delay. As ROP is significantly associated with poor neurodevelopmental outcomes independent of extreme prematurity, neurodevelopmental functions should be given attention in infants with ROP. |
| first_indexed | 2024-04-13T16:31:23Z |
| format | Article |
| id | doaj.art-6b1f690d1572422e9e71e9a23aec41fb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T16:31:23Z |
| publishDate | 2022-03-01 |
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| series | Scientific Reports |
| spelling | doaj.art-6b1f690d1572422e9e71e9a23aec41fb2022-12-22T02:39:33ZengNature PortfolioScientific Reports2045-23222022-03-011211810.1038/s41598-022-09053-8Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort studyJa-Hye Ahn0Kyeong Mi Lee1Mi Jung Kim2Hyun-Kyung Park3Yu Jeong Kim4Seong Joon Ahn5Hyun Ju Lee6Division of Neonatology and Developmental Medicine, Hanyang University HospitalDivision of Neonatology and Developmental Medicine, Hanyang University HospitalDepartment of Rehabilitation Medicine, Hanyang University College of MedicineDivision of Neonatology and Developmental Medicine, Hanyang University HospitalDepartment of Ophthalmology, Hanyang University Hospital, Hanyang University College of MedicineDepartment of Ophthalmology, Hanyang University Hospital, Hanyang University College of MedicineDivision of Neonatology and Developmental Medicine, Hanyang University HospitalAbstract In a nationwide prospective cohort of Korean infants with very low birthweights (VLBW, birth weight < 1500 g) from 70 neonatal intensive care units of the Korean Neonatal Network, we investigated neurodevelopmental outcomes in preterm infants with retinopathy of prematurity (ROP) from 2132 infants with VLBW who had undergone developmental assessments at 18–24 months of corrected age. Motor, cognitive, or language delay was determined using developmental scores that were less than 1 standard deviation from the average. Comparative analyses and multivariate regression analyses were performed to validate the association between ROP or its treatment and developmental delay. Motor (52.8% vs. 36.3%), cognitive (46.8% vs. 31.6%), and language delays (42.5% vs. 28.4%) were noted more frequently in infants with ROP than in those without ROP; this was statistically significant (all P < 0.001). Multivariate analyses showed that motor and cognitive delays were significantly associated with ROP. There were no remarkable differences between the neurodevelopmental outcomes and the treatment modalities (laser photocoagulation, anti-vascular endothelial growth factor injection, or both) for ROP, and both stratification and multivariate regression analyses confirmed no significant association between anti-vascular endothelial growth factor therapy and neurodevelopmental delay. As ROP is significantly associated with poor neurodevelopmental outcomes independent of extreme prematurity, neurodevelopmental functions should be given attention in infants with ROP.https://doi.org/10.1038/s41598-022-09053-8 |
| spellingShingle | Ja-Hye Ahn Kyeong Mi Lee Mi Jung Kim Hyun-Kyung Park Yu Jeong Kim Seong Joon Ahn Hyun Ju Lee Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study Scientific Reports |
| title | Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study |
| title_full | Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study |
| title_fullStr | Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study |
| title_full_unstemmed | Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study |
| title_short | Neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study |
| title_sort | neurodevelopmental outcomes in very low birthweight infants with retinopathy of prematurity in a nationwide cohort study |
| url | https://doi.org/10.1038/s41598-022-09053-8 |
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