Advances in the Electrophysiological Recordings of Long-Term Potentiation
Understanding neuronal firing patterns and long-term potentiation (LTP) induction in studying learning, memory, and neurological diseases is critical. However, recently, despite the rapid advancement in neuroscience, we are still constrained by the experimental design, detection tools for exploring...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7134 |
| _version_ | 1797605157344641024 |
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| author | Feixu Jiang Stephen Temitayo Bello Qianqian Gao Yuanying Lai Xiao Li Ling He |
| author_facet | Feixu Jiang Stephen Temitayo Bello Qianqian Gao Yuanying Lai Xiao Li Ling He |
| author_sort | Feixu Jiang |
| collection | DOAJ |
| description | Understanding neuronal firing patterns and long-term potentiation (LTP) induction in studying learning, memory, and neurological diseases is critical. However, recently, despite the rapid advancement in neuroscience, we are still constrained by the experimental design, detection tools for exploring the mechanisms and pathways involved in LTP induction, and detection ability of neuronal action potentiation signals. This review will reiterate LTP-related electrophysiological recordings in the mammalian brain for nearly 50 years and explain how excitatory and inhibitory neural LTP results have been detected and described by field- and single-cell potentials, respectively. Furthermore, we focus on describing the classic model of LTP of inhibition and discuss the inhibitory neuron activity when excitatory neurons are activated to induce LTP. Finally, we propose recording excitatory and inhibitory neurons under the same experimental conditions by combining various electrophysiological technologies and novel design suggestions for future research. We discussed different types of synaptic plasticity, and the potential of astrocytes to induce LTP also deserves to be explored in the future. |
| first_indexed | 2024-03-11T04:57:08Z |
| format | Article |
| id | doaj.art-6b206d464c3f4a7a8920c2822d8bb356 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:57:08Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6b206d464c3f4a7a8920c2822d8bb3562023-11-17T19:35:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248713410.3390/ijms24087134Advances in the Electrophysiological Recordings of Long-Term PotentiationFeixu Jiang0Stephen Temitayo Bello1Qianqian Gao2Yuanying Lai3Xiao Li4Ling He5Department of Neuroscience, City University of Hong Kong, Kowloon, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong KongDepartment of Neuroscience, City University of Hong Kong, Kowloon, Hong KongUnderstanding neuronal firing patterns and long-term potentiation (LTP) induction in studying learning, memory, and neurological diseases is critical. However, recently, despite the rapid advancement in neuroscience, we are still constrained by the experimental design, detection tools for exploring the mechanisms and pathways involved in LTP induction, and detection ability of neuronal action potentiation signals. This review will reiterate LTP-related electrophysiological recordings in the mammalian brain for nearly 50 years and explain how excitatory and inhibitory neural LTP results have been detected and described by field- and single-cell potentials, respectively. Furthermore, we focus on describing the classic model of LTP of inhibition and discuss the inhibitory neuron activity when excitatory neurons are activated to induce LTP. Finally, we propose recording excitatory and inhibitory neurons under the same experimental conditions by combining various electrophysiological technologies and novel design suggestions for future research. We discussed different types of synaptic plasticity, and the potential of astrocytes to induce LTP also deserves to be explored in the future.https://www.mdpi.com/1422-0067/24/8/7134LTPiLTPelectrophysiological experimentsfield potential recordingsingle-cell potential recordingastrocytes |
| spellingShingle | Feixu Jiang Stephen Temitayo Bello Qianqian Gao Yuanying Lai Xiao Li Ling He Advances in the Electrophysiological Recordings of Long-Term Potentiation International Journal of Molecular Sciences LTP iLTP electrophysiological experiments field potential recording single-cell potential recording astrocytes |
| title | Advances in the Electrophysiological Recordings of Long-Term Potentiation |
| title_full | Advances in the Electrophysiological Recordings of Long-Term Potentiation |
| title_fullStr | Advances in the Electrophysiological Recordings of Long-Term Potentiation |
| title_full_unstemmed | Advances in the Electrophysiological Recordings of Long-Term Potentiation |
| title_short | Advances in the Electrophysiological Recordings of Long-Term Potentiation |
| title_sort | advances in the electrophysiological recordings of long term potentiation |
| topic | LTP iLTP electrophysiological experiments field potential recording single-cell potential recording astrocytes |
| url | https://www.mdpi.com/1422-0067/24/8/7134 |
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