MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment
Modeling and remodeling are essential processes in the development and refinement of maxillofacial bones. Dysregulated bone modeling during the developmental stage may lead to maxillofacial bone malformations and malocclusion. Bone remodeling under mechanical loading serves as the biological basis f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1355312/full |
| _version_ | 1797263670401564672 |
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| author | Baike Chen Yuxin Zhang Ousheng Liu |
| author_facet | Baike Chen Yuxin Zhang Ousheng Liu |
| author_sort | Baike Chen |
| collection | DOAJ |
| description | Modeling and remodeling are essential processes in the development and refinement of maxillofacial bones. Dysregulated bone modeling during the developmental stage may lead to maxillofacial bone malformations and malocclusion. Bone remodeling under mechanical loading serves as the biological basis for orthodontic treatment. Although previous reviews have indicated the significance of microRNAs (miRNAs) in bone metabolism, their roles in orchestrating maxillofacial bone modeling and remodeling remain unclear. This review aims to discuss the mechanisms by which miRNAs regulate the morphogenesis and development of maxillofacial bones, as well as their implications for maxillofacial malformations and malocclusion. Moreover, miRNAs participating in maxillofacial bone remodeling and their impacts on cell mechanosensing are also summarized. Given the intricate interplay of cells and signaling pathways, exosomal miRNAs emerge as the orchestrators of the modeling and remodeling processes. The diagnostic and therapeutic potentials of miRNAs are also highlighted in this review for future clinical applications. |
| first_indexed | 2024-04-25T00:16:42Z |
| format | Article |
| id | doaj.art-6b20d8bcb3264eab8d51c0f13c10c95c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-25T00:16:42Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6b20d8bcb3264eab8d51c0f13c10c95c2024-03-13T04:17:07ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-03-011210.3389/fcell.2024.13553121355312MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatmentBaike ChenYuxin ZhangOusheng LiuModeling and remodeling are essential processes in the development and refinement of maxillofacial bones. Dysregulated bone modeling during the developmental stage may lead to maxillofacial bone malformations and malocclusion. Bone remodeling under mechanical loading serves as the biological basis for orthodontic treatment. Although previous reviews have indicated the significance of microRNAs (miRNAs) in bone metabolism, their roles in orchestrating maxillofacial bone modeling and remodeling remain unclear. This review aims to discuss the mechanisms by which miRNAs regulate the morphogenesis and development of maxillofacial bones, as well as their implications for maxillofacial malformations and malocclusion. Moreover, miRNAs participating in maxillofacial bone remodeling and their impacts on cell mechanosensing are also summarized. Given the intricate interplay of cells and signaling pathways, exosomal miRNAs emerge as the orchestrators of the modeling and remodeling processes. The diagnostic and therapeutic potentials of miRNAs are also highlighted in this review for future clinical applications.https://www.frontiersin.org/articles/10.3389/fcell.2024.1355312/fullmiRNAorthodontic treatmentbone modelingbone remodelingmaxillofacial bonemalocclusion |
| spellingShingle | Baike Chen Yuxin Zhang Ousheng Liu MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment Frontiers in Cell and Developmental Biology miRNA orthodontic treatment bone modeling bone remodeling maxillofacial bone malocclusion |
| title | MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment |
| title_full | MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment |
| title_fullStr | MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment |
| title_full_unstemmed | MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment |
| title_short | MicroRNAs in maxillofacial bone modeling and remodeling: implications for malocclusion development and orthodontic treatment |
| title_sort | micrornas in maxillofacial bone modeling and remodeling implications for malocclusion development and orthodontic treatment |
| topic | miRNA orthodontic treatment bone modeling bone remodeling maxillofacial bone malocclusion |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1355312/full |
| work_keys_str_mv | AT baikechen micrornasinmaxillofacialbonemodelingandremodelingimplicationsformalocclusiondevelopmentandorthodontictreatment AT yuxinzhang micrornasinmaxillofacialbonemodelingandremodelingimplicationsformalocclusiondevelopmentandorthodontictreatment AT oushengliu micrornasinmaxillofacialbonemodelingandremodelingimplicationsformalocclusiondevelopmentandorthodontictreatment |