A heparin-modified thermoresponsive surface with heparin-binding epidermal growth factor-like growth factor for maintaining hepatic functions in vitro and harvesting hepatocyte sheets

A heparin-modified thermoresponsive surface with heparin-binding epidermal growth factor-like growth factor for maintaining hepatic functions in vitro and harvesting hepatocyte sheets

A heparin-modified thermoresponsive surface bound with heparin-binding epidermal growth factor-like growth factor (HB-EGF) was designed to allow creation of transferrable and functional hepatocyte sheets. A heparin-modified thermoresponsive surface was prepared by covalently tethering heparin onto p...

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Bibliographic Details
Main Authors: Yoshinori Arisaka, Jun Kobayashi, Kazuo Ohashi, Kohei Tatsumi, Kyungsook Kim, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Regenerative Therapy
Subjects:
Poly(N-isopropylacrylamide)
Thermoresponsive cell culture surface
Heparin
Heparin-binding EGF-like growth factor
Hepatocyte sheet
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320416000262

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