MYCN in Neuroblastoma: “Old Wine into New Wineskins”
MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent targets for neuroblastoma therapy. In the present w...
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MDPI AG
2021-10-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/9/4/78 |
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| author | Maria Braoudaki Kyriaki Hatziagapiou Apostolos Zaravinos George I. Lambrou |
| author_facet | Maria Braoudaki Kyriaki Hatziagapiou Apostolos Zaravinos George I. Lambrou |
| author_sort | Maria Braoudaki |
| collection | DOAJ |
| description | MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent targets for neuroblastoma therapy. In the present work, we attempted to review the literature, on the relation between MYCN and neuroblastoma from all possible mechanistic sites. We have searched the literature for the role of MYCN in neuroblastoma based on the following topics: the references of MYCN in the literature, the gene’s anatomy, along with its transcripts, the protein’s anatomy, the epigenetic mechanisms regulating MYCN expression and function, as well as MYCN amplification. <i>MYCN</i> plays a significant role in neuroblastoma biology. Its functions and properties range from the forming of G-quadraplexes, to the interaction with miRNAs, as well as the regulation of gene methylation and histone acetylation and deacetylation. Although <i>MYCN</i> is one of the most primary genes studied in neuroblastoma, there is still a lot to be learned. Our knowledge on the exact mechanisms of MYCN amplification, etiology and potential interventions is still limited. The knowledge on the molecular mechanisms of MYCN in neuroblastoma, could have potential prognostic and therapeutic advantages. |
| first_indexed | 2024-03-10T04:18:01Z |
| format | Article |
| id | doaj.art-6b225569d0d7427691b427de268eae0e |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-10T04:18:01Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-6b225569d0d7427691b427de268eae0e2023-11-23T07:55:48ZengMDPI AGDiseases2079-97212021-10-01947810.3390/diseases9040078MYCN in Neuroblastoma: “Old Wine into New Wineskins”Maria Braoudaki0Kyriaki Hatziagapiou1Apostolos Zaravinos2George I. Lambrou3Department of Life and Environmental Sciences, School of Life and Health Sciences, University of Hertfordshire, Hatfield AL10 9AB, Hertfordshire, UKChoremeio Research Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias 8, Goudi, 11527 Athens, GreeceDepartment of Life Sciences, European University Cyprus, Diogenis Str., 6, Nicosia 2404, CyprusChoremeio Research Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias 8, Goudi, 11527 Athens, GreeceMYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent targets for neuroblastoma therapy. In the present work, we attempted to review the literature, on the relation between MYCN and neuroblastoma from all possible mechanistic sites. We have searched the literature for the role of MYCN in neuroblastoma based on the following topics: the references of MYCN in the literature, the gene’s anatomy, along with its transcripts, the protein’s anatomy, the epigenetic mechanisms regulating MYCN expression and function, as well as MYCN amplification. <i>MYCN</i> plays a significant role in neuroblastoma biology. Its functions and properties range from the forming of G-quadraplexes, to the interaction with miRNAs, as well as the regulation of gene methylation and histone acetylation and deacetylation. Although <i>MYCN</i> is one of the most primary genes studied in neuroblastoma, there is still a lot to be learned. Our knowledge on the exact mechanisms of MYCN amplification, etiology and potential interventions is still limited. The knowledge on the molecular mechanisms of MYCN in neuroblastoma, could have potential prognostic and therapeutic advantages.https://www.mdpi.com/2079-9721/9/4/78MYCNamplificationepigenetic regulationacetylationG-quadraplexneuroblastoma |
| spellingShingle | Maria Braoudaki Kyriaki Hatziagapiou Apostolos Zaravinos George I. Lambrou MYCN in Neuroblastoma: “Old Wine into New Wineskins” Diseases MYCN amplification epigenetic regulation acetylation G-quadraplex neuroblastoma |
| title | MYCN in Neuroblastoma: “Old Wine into New Wineskins” |
| title_full | MYCN in Neuroblastoma: “Old Wine into New Wineskins” |
| title_fullStr | MYCN in Neuroblastoma: “Old Wine into New Wineskins” |
| title_full_unstemmed | MYCN in Neuroblastoma: “Old Wine into New Wineskins” |
| title_short | MYCN in Neuroblastoma: “Old Wine into New Wineskins” |
| title_sort | mycn in neuroblastoma old wine into new wineskins |
| topic | MYCN amplification epigenetic regulation acetylation G-quadraplex neuroblastoma |
| url | https://www.mdpi.com/2079-9721/9/4/78 |
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