Long-term health after Severe Acute Malnutrition in children and adults- the role of the Pancreas (SAMPA): Protocol [version 2; peer review: 2 approved]
Background: Prenatal growth retardation may increase the risk of later chronic non-communicable diseases (NCDs), including diabetes; however, long-term effects of wasting malnutrition in childhood or adulthood are less studied. Pancreatic exocrine and endocrine functions, both critical for nutrition...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2022-10-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/11-777/v2 |
| _version_ | 1798031210122838016 |
|---|---|
| author | Dixi M. Paglinawan-Modoc Juan Solon Rikke Krogh-Madsen James AM Shaw Belinda Kweka Daniel Faurholt-Jepsen Geeta Trilok-Kumar Molly Chisenga Nanette R. Lee Paul Kelly Sana Ahmed George PrayGod Ruth Keogh Suzanne Filteau Sharon Cox Dorothea Nitsch Mette Frahm Olsen Darko Stefanovski |
| author_facet | Dixi M. Paglinawan-Modoc Juan Solon Rikke Krogh-Madsen James AM Shaw Belinda Kweka Daniel Faurholt-Jepsen Geeta Trilok-Kumar Molly Chisenga Nanette R. Lee Paul Kelly Sana Ahmed George PrayGod Ruth Keogh Suzanne Filteau Sharon Cox Dorothea Nitsch Mette Frahm Olsen Darko Stefanovski |
| author_sort | Dixi M. Paglinawan-Modoc |
| collection | DOAJ |
| description | Background: Prenatal growth retardation may increase the risk of later chronic non-communicable diseases (NCDs), including diabetes; however, long-term effects of wasting malnutrition in childhood or adulthood are less studied. Pancreatic exocrine and endocrine functions, both critical for nutrition and NCD aetiology, may not fully recover following malnutrition. However, the evidence and mechanistic information is piecemeal. We hypothesise that wasting malnutrition at any age has long-term detrimental effects on endocrine and exocrine pancreatic structure and function. Methods: The SAMPA international research programme will assess pancreatic structure and function in 3700 participants from ongoing observational nutrition cohorts, two adolescent and four adult, in Zambia, Tanzania, Philippines, and India. Pancreas size, structure, and calcification will be assessed by ultrasound and computed tomography (CT) scan; exocrine function by faecal elastase and serum lipase; and endocrine function by haemoglobin A1c (HbA1c) and blood glucose, insulin and C-peptide concentrations during an oral glucose tolerance test (OGTT). In-depth hormonal analyses of incretins, glucagon, proinsulin and trypsinogen during OGTT and intravenous glucose tolerance tests will be done in subsets of adult participants. Pancreatic size and function outcomes will be compared between people with and without prior wasting malnutrition. Analyses will investigate effect modification by sex, current age, time since malnutrition, current body mass index and dietary patterns. Mathematical modelling of OGTT data will be used to estimate the relative contribution to glucose dysregulation of decreased insulin production, changes in insulin clearance and increased insulin resistance. Proinsulin/insulin ratio will be analysed in archived samples from the Tanzanian cohort using a nested case-control design to investigate whether abnormal values precede diabetes. Conclusions: SAMPA, a large-scale multi-centre research programme using data from people with or without prior wasting malnutrition to assess several aspects of pancreatic phenotype, will provide coherent evidence for future policies and programmes for malnutrition and diabetes. |
| first_indexed | 2024-04-11T19:52:43Z |
| format | Article |
| id | doaj.art-6b23168b30de4b2d9f7fea054f414f81 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-11T19:52:43Z |
| publishDate | 2022-10-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-6b23168b30de4b2d9f7fea054f414f812022-12-22T04:06:15ZengF1000 Research LtdF1000Research2046-14022022-10-0111139279Long-term health after Severe Acute Malnutrition in children and adults- the role of the Pancreas (SAMPA): Protocol [version 2; peer review: 2 approved]Dixi M. Paglinawan-Modoc0Juan Solon1Rikke Krogh-Madsen2James AM Shaw3Belinda Kweka4Daniel Faurholt-Jepsen5Geeta Trilok-Kumar6Molly Chisenga7Nanette R. Lee8Paul Kelly9Sana Ahmed10https://orcid.org/0000-0002-1658-6574George PrayGod11Ruth Keogh12Suzanne Filteau13Sharon Cox14https://orcid.org/0000-0002-9908-2936Dorothea Nitsch15Mette Frahm Olsen16Darko Stefanovski17Nutrition Center of the Philippines, Muntinlupa City, Manila, PhilippinesNutrition Center of the Philippines, Muntinlupa City, Manila, PhilippinesCentre for Physical Activity Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, DenmarkTranslational and Clinical Research Institute, Newcastle University, The Medical School, Framlington Place, Newcastle-upon-Tyne, UKNational Institute for Medical Research, Mwanza, TanzaniaDepartment of Infectious Diseases, Rigshospitalet, Copenhagen, 2100, DenmarkInstitute of Home Economics, University of Delhi, Delhi, 110016, IndiaUniversity Teaching Hospital, Lusaka, ZambiaUSC-Office of Population Studies Foundation, Inc., University of San Carlos, Populations Studies Foundation, Cebu City, 6000, PhilippinesUniversity Teaching Hospital, Lusaka, ZambiaInstitute of Home Economics, University of Delhi, Delhi, 110016, IndiaNational Institute for Medical Research, Mwanza, TanzaniaFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UKFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UKFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UKFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UKDepartment of Infectious Diseases, Rigshospitalet, Copenhagen, 2100, DenmarkDepartment of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Philadelphia, USABackground: Prenatal growth retardation may increase the risk of later chronic non-communicable diseases (NCDs), including diabetes; however, long-term effects of wasting malnutrition in childhood or adulthood are less studied. Pancreatic exocrine and endocrine functions, both critical for nutrition and NCD aetiology, may not fully recover following malnutrition. However, the evidence and mechanistic information is piecemeal. We hypothesise that wasting malnutrition at any age has long-term detrimental effects on endocrine and exocrine pancreatic structure and function. Methods: The SAMPA international research programme will assess pancreatic structure and function in 3700 participants from ongoing observational nutrition cohorts, two adolescent and four adult, in Zambia, Tanzania, Philippines, and India. Pancreas size, structure, and calcification will be assessed by ultrasound and computed tomography (CT) scan; exocrine function by faecal elastase and serum lipase; and endocrine function by haemoglobin A1c (HbA1c) and blood glucose, insulin and C-peptide concentrations during an oral glucose tolerance test (OGTT). In-depth hormonal analyses of incretins, glucagon, proinsulin and trypsinogen during OGTT and intravenous glucose tolerance tests will be done in subsets of adult participants. Pancreatic size and function outcomes will be compared between people with and without prior wasting malnutrition. Analyses will investigate effect modification by sex, current age, time since malnutrition, current body mass index and dietary patterns. Mathematical modelling of OGTT data will be used to estimate the relative contribution to glucose dysregulation of decreased insulin production, changes in insulin clearance and increased insulin resistance. Proinsulin/insulin ratio will be analysed in archived samples from the Tanzanian cohort using a nested case-control design to investigate whether abnormal values precede diabetes. Conclusions: SAMPA, a large-scale multi-centre research programme using data from people with or without prior wasting malnutrition to assess several aspects of pancreatic phenotype, will provide coherent evidence for future policies and programmes for malnutrition and diabetes.https://f1000research.com/articles/11-777/v2Malnutrition wasting diabetes pancreas non-communicable diseases oral glucose tolerance testeng |
| spellingShingle | Dixi M. Paglinawan-Modoc Juan Solon Rikke Krogh-Madsen James AM Shaw Belinda Kweka Daniel Faurholt-Jepsen Geeta Trilok-Kumar Molly Chisenga Nanette R. Lee Paul Kelly Sana Ahmed George PrayGod Ruth Keogh Suzanne Filteau Sharon Cox Dorothea Nitsch Mette Frahm Olsen Darko Stefanovski Long-term health after Severe Acute Malnutrition in children and adults- the role of the Pancreas (SAMPA): Protocol [version 2; peer review: 2 approved] F1000Research Malnutrition wasting diabetes pancreas non-communicable diseases oral glucose tolerance test eng |
| title | Long-term health after Severe Acute Malnutrition in children and adults- the role of the Pancreas (SAMPA): Protocol [version 2; peer review: 2 approved] |
| title_full | Long-term health after Severe Acute Malnutrition in children and adults- the role of the Pancreas (SAMPA): Protocol [version 2; peer review: 2 approved] |
| title_fullStr | Long-term health after Severe Acute Malnutrition in children and adults- the role of the Pancreas (SAMPA): Protocol [version 2; peer review: 2 approved] |
| title_full_unstemmed | Long-term health after Severe Acute Malnutrition in children and adults- the role of the Pancreas (SAMPA): Protocol [version 2; peer review: 2 approved] |
| title_short | Long-term health after Severe Acute Malnutrition in children and adults- the role of the Pancreas (SAMPA): Protocol [version 2; peer review: 2 approved] |
| title_sort | long term health after severe acute malnutrition in children and adults the role of the pancreas sampa protocol version 2 peer review 2 approved |
| topic | Malnutrition wasting diabetes pancreas non-communicable diseases oral glucose tolerance test eng |
| url | https://f1000research.com/articles/11-777/v2 |
| work_keys_str_mv | AT diximpaglinawanmodoc longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT juansolon longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT rikkekroghmadsen longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT jamesamshaw longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT belindakweka longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT danielfaurholtjepsen longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT geetatrilokkumar longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT mollychisenga longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT nanetterlee longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT paulkelly longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT sanaahmed longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT georgepraygod longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT ruthkeogh longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT suzannefilteau longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT sharoncox longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT dorotheanitsch longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT mettefrahmolsen longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved AT darkostefanovski longtermhealthaftersevereacutemalnutritioninchildrenandadultstheroleofthepancreassampaprotocolversion2peerreview2approved |