Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development
Metaplasticity refers to adjustment in the requirements for induction of synaptic plasticity based on the prior history of activity. Numerous forms of developmental metaplasticity are observed at Schaffer collateral synapses in the rat hippocampus at the end of the third postnatal week. Emergence of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-04-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929315000237 |
| _version_ | 1818759360066617344 |
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| author | Daniel G. McHail Theodore C. Dumas |
| author_facet | Daniel G. McHail Theodore C. Dumas |
| author_sort | Daniel G. McHail |
| collection | DOAJ |
| description | Metaplasticity refers to adjustment in the requirements for induction of synaptic plasticity based on the prior history of activity. Numerous forms of developmental metaplasticity are observed at Schaffer collateral synapses in the rat hippocampus at the end of the third postnatal week. Emergence of spatial learning and memory at this developmental stage suggests possible involvement of metaplasticity in the final maturation of the hippocampus. Three distinct metaplastic phenomena are apparent. (1) As transmitter release probability increases with increasing age, presynaptic potentiation is reduced. (2) Alterations in the composition and channel conductance properties of AMPARs facilitate the induction of postsynaptic potentiation with increasing age. (3) Low frequency stimulation inhibits subsequent induction of potentiation in animals older but not younger than 3 weeks of age. Thus, many forms of plasticity expressed at SC-CA1 synapses are different in rats younger and older than 3 weeks of age, illustrating the complex orchestration of physiological modifications that underlie the maturation of hippocampal excitatory synaptic transmission. This review paper describes three late postnatal modifications to synaptic plasticity induction in the hippocampus and attempts to relate these metaplastic changes to developmental alterations in hippocampal network activity and the maturation of contextual learning. |
| first_indexed | 2024-12-18T06:41:29Z |
| format | Article |
| id | doaj.art-6b23576836c74ca5893919a1ee42df86 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 1878-9307 |
| language | English |
| last_indexed | 2024-12-18T06:41:29Z |
| publishDate | 2015-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-6b23576836c74ca5893919a1ee42df862022-12-21T21:17:37ZengElsevierDevelopmental Cognitive Neuroscience1878-92931878-93072015-04-0112C14515410.1016/j.dcn.2015.01.009Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal developmentDaniel G. McHailTheodore C. DumasMetaplasticity refers to adjustment in the requirements for induction of synaptic plasticity based on the prior history of activity. Numerous forms of developmental metaplasticity are observed at Schaffer collateral synapses in the rat hippocampus at the end of the third postnatal week. Emergence of spatial learning and memory at this developmental stage suggests possible involvement of metaplasticity in the final maturation of the hippocampus. Three distinct metaplastic phenomena are apparent. (1) As transmitter release probability increases with increasing age, presynaptic potentiation is reduced. (2) Alterations in the composition and channel conductance properties of AMPARs facilitate the induction of postsynaptic potentiation with increasing age. (3) Low frequency stimulation inhibits subsequent induction of potentiation in animals older but not younger than 3 weeks of age. Thus, many forms of plasticity expressed at SC-CA1 synapses are different in rats younger and older than 3 weeks of age, illustrating the complex orchestration of physiological modifications that underlie the maturation of hippocampal excitatory synaptic transmission. This review paper describes three late postnatal modifications to synaptic plasticity induction in the hippocampus and attempts to relate these metaplastic changes to developmental alterations in hippocampal network activity and the maturation of contextual learning.http://www.sciencedirect.com/science/article/pii/S1878929315000237HippocampusMetaplasticityPostnatal developmentLong-term depressionLong-term potentiationSchaffer collateral |
| spellingShingle | Daniel G. McHail Theodore C. Dumas Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development Developmental Cognitive Neuroscience Hippocampus Metaplasticity Postnatal development Long-term depression Long-term potentiation Schaffer collateral |
| title | Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development |
| title_full | Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development |
| title_fullStr | Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development |
| title_full_unstemmed | Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development |
| title_short | Multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development |
| title_sort | multiple forms of metaplasticity at a single hippocampal synapse during late postnatal development |
| topic | Hippocampus Metaplasticity Postnatal development Long-term depression Long-term potentiation Schaffer collateral |
| url | http://www.sciencedirect.com/science/article/pii/S1878929315000237 |
| work_keys_str_mv | AT danielgmchail multipleformsofmetaplasticityatasinglehippocampalsynapseduringlatepostnataldevelopment AT theodorecdumas multipleformsofmetaplasticityatasinglehippocampalsynapseduringlatepostnataldevelopment |