Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl
ABSTRACTBalamuthia amoebic encephalitis has a subacute-to-chronic course and is almost invariably fatal owing to delayed diagnosis and a lack of effective therapy. Here, we report a 13-year-old girl with cutaneous lesions and multifocal granulomatous encephalitis. The patient underwent a series of t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1775130 |
| _version_ | 1797265806194638848 |
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| author | Xia Wu Gangfeng Yan Shuzhen Han Yingzi Ye Xunjia Cheng Hairong Gong Hui Yu |
| author_facet | Xia Wu Gangfeng Yan Shuzhen Han Yingzi Ye Xunjia Cheng Hairong Gong Hui Yu |
| author_sort | Xia Wu |
| collection | DOAJ |
| description | ABSTRACTBalamuthia amoebic encephalitis has a subacute-to-chronic course and is almost invariably fatal owing to delayed diagnosis and a lack of effective therapy. Here, we report a 13-year-old girl with cutaneous lesions and multifocal granulomatous encephalitis. The patient underwent a series of tests and was suspected as having tuberculosis. She was treated with various empiric therapies without improvement. She was finally correctly diagnosed via next-generation sequencing of the cerebrospinal fluid. The patient deteriorated rapidly and died 2 months after being diagnosed with Balamuthia mandrillaris encephalitis. This study highlights the important clinical significance of next-generation sequencing, which provides better diagnostic testing for unexplained paediatric encephalitis, especially that caused by rare or emerging pathogens. |
| first_indexed | 2024-03-07T17:24:01Z |
| format | Article |
| id | doaj.art-6b2478131af34c14a8512a87a6469e64 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-25T00:50:39Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-6b2478131af34c14a8512a87a6469e642024-03-11T16:04:25ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-01911379138710.1080/22221751.2020.1775130Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girlXia Wu0Gangfeng Yan1Shuzhen Han2Yingzi Ye3Xunjia Cheng4Hairong Gong5Hui Yu6Department of Infectious Diseases, Children’s Hospital of Fudan University, Shanghai, People’s Republic of ChinaDepartment of Pediatric Emergency Medicine and Critical Care Medicine, Children’s Hospital of Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, Children’s Hospital of Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, Children’s Hospital of Fudan University, Shanghai, People’s Republic of ChinaDepartment of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Pediatric Emergency Medicine and Critical Care Medicine, Children’s Hospital of Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, Children’s Hospital of Fudan University, Shanghai, People’s Republic of ChinaABSTRACTBalamuthia amoebic encephalitis has a subacute-to-chronic course and is almost invariably fatal owing to delayed diagnosis and a lack of effective therapy. Here, we report a 13-year-old girl with cutaneous lesions and multifocal granulomatous encephalitis. The patient underwent a series of tests and was suspected as having tuberculosis. She was treated with various empiric therapies without improvement. She was finally correctly diagnosed via next-generation sequencing of the cerebrospinal fluid. The patient deteriorated rapidly and died 2 months after being diagnosed with Balamuthia mandrillaris encephalitis. This study highlights the important clinical significance of next-generation sequencing, which provides better diagnostic testing for unexplained paediatric encephalitis, especially that caused by rare or emerging pathogens.https://www.tandfonline.com/doi/10.1080/22221751.2020.1775130Balamuthia mandrillarisBalamuthia amoebic encephalitisgranulomatous amebic encephalitisnext-generation sequencingchildren |
| spellingShingle | Xia Wu Gangfeng Yan Shuzhen Han Yingzi Ye Xunjia Cheng Hairong Gong Hui Yu Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl Emerging Microbes and Infections Balamuthia mandrillaris Balamuthia amoebic encephalitis granulomatous amebic encephalitis next-generation sequencing children |
| title | Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl |
| title_full | Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl |
| title_fullStr | Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl |
| title_full_unstemmed | Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl |
| title_short | Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl |
| title_sort | diagnosing balamuthia mandrillaris encephalitis via next generation sequencing in a 13 year old girl |
| topic | Balamuthia mandrillaris Balamuthia amoebic encephalitis granulomatous amebic encephalitis next-generation sequencing children |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1775130 |
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