Survival nomogram for curatively resected Korean gastric cancer patients: multicenter retrospective analysis with external validation.
A small number of nomograms have been previously developed to predict the individual survival of patients who undergo curative resection for gastric cancer. However, all were derived from single high-volume centers. The aim of this study was to develop and validate a nomogram for gastric cancer pati...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4344235?pdf=render |
| _version_ | 1818844075058528256 |
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| author | Bang Wool Eom Keun Won Ryu Byung-Ho Nam Yunjin Park Hyuk-Joon Lee Min Chan Kim Gyu Seok Cho Chan Young Kim Seung Wan Ryu Dong Woo Shin Woo Jin Hyung Jun Ho Lee |
| author_facet | Bang Wool Eom Keun Won Ryu Byung-Ho Nam Yunjin Park Hyuk-Joon Lee Min Chan Kim Gyu Seok Cho Chan Young Kim Seung Wan Ryu Dong Woo Shin Woo Jin Hyung Jun Ho Lee |
| author_sort | Bang Wool Eom |
| collection | DOAJ |
| description | A small number of nomograms have been previously developed to predict the individual survival of patients who undergo curative resection for gastric cancer. However, all were derived from single high-volume centers. The aim of this study was to develop and validate a nomogram for gastric cancer patients using a multicenter database.We reviewed the clinicopathological and survival data of 2012 patients who underwent curative resection for gastric cancer between 2001 and 2006 at eight centers. Among these centers, six institutions were randomly assigned to the development set, and the other two centers were assigned to the validation set. Multivariate analysis using the Cox proportional hazard regression model was performed, and discrimination and calibration were evaluated by external validation.Multivariate analyses revealed that age, tumor size, lymphovascular invasion, depth of invasion, and metastatic lymph nodes were significant prognostic factors for overall survival. In the external validation, the concordance index was 0.831 (95% confidence interval, 0.784-0.878), and Hosmer-Lemeshow chi-square statistic was 3.92 (P = 0.917).We developed and validated a nomogram to predict 5-year overall survival after curative resection for gastric cancer based on a multicenter database. This nomogram can be broadly applied even in general hospitals and is useful for counseling patients, and scheduling follow-up. |
| first_indexed | 2024-12-19T05:07:59Z |
| format | Article |
| id | doaj.art-6b28360d44b14f6eb718a05cdff43702 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T05:07:59Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6b28360d44b14f6eb718a05cdff437022022-12-21T20:34:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011967110.1371/journal.pone.0119671Survival nomogram for curatively resected Korean gastric cancer patients: multicenter retrospective analysis with external validation.Bang Wool EomKeun Won RyuByung-Ho NamYunjin ParkHyuk-Joon LeeMin Chan KimGyu Seok ChoChan Young KimSeung Wan RyuDong Woo ShinWoo Jin HyungJun Ho LeeA small number of nomograms have been previously developed to predict the individual survival of patients who undergo curative resection for gastric cancer. However, all were derived from single high-volume centers. The aim of this study was to develop and validate a nomogram for gastric cancer patients using a multicenter database.We reviewed the clinicopathological and survival data of 2012 patients who underwent curative resection for gastric cancer between 2001 and 2006 at eight centers. Among these centers, six institutions were randomly assigned to the development set, and the other two centers were assigned to the validation set. Multivariate analysis using the Cox proportional hazard regression model was performed, and discrimination and calibration were evaluated by external validation.Multivariate analyses revealed that age, tumor size, lymphovascular invasion, depth of invasion, and metastatic lymph nodes were significant prognostic factors for overall survival. In the external validation, the concordance index was 0.831 (95% confidence interval, 0.784-0.878), and Hosmer-Lemeshow chi-square statistic was 3.92 (P = 0.917).We developed and validated a nomogram to predict 5-year overall survival after curative resection for gastric cancer based on a multicenter database. This nomogram can be broadly applied even in general hospitals and is useful for counseling patients, and scheduling follow-up.http://europepmc.org/articles/PMC4344235?pdf=render |
| spellingShingle | Bang Wool Eom Keun Won Ryu Byung-Ho Nam Yunjin Park Hyuk-Joon Lee Min Chan Kim Gyu Seok Cho Chan Young Kim Seung Wan Ryu Dong Woo Shin Woo Jin Hyung Jun Ho Lee Survival nomogram for curatively resected Korean gastric cancer patients: multicenter retrospective analysis with external validation. PLoS ONE |
| title | Survival nomogram for curatively resected Korean gastric cancer patients: multicenter retrospective analysis with external validation. |
| title_full | Survival nomogram for curatively resected Korean gastric cancer patients: multicenter retrospective analysis with external validation. |
| title_fullStr | Survival nomogram for curatively resected Korean gastric cancer patients: multicenter retrospective analysis with external validation. |
| title_full_unstemmed | Survival nomogram for curatively resected Korean gastric cancer patients: multicenter retrospective analysis with external validation. |
| title_short | Survival nomogram for curatively resected Korean gastric cancer patients: multicenter retrospective analysis with external validation. |
| title_sort | survival nomogram for curatively resected korean gastric cancer patients multicenter retrospective analysis with external validation |
| url | http://europepmc.org/articles/PMC4344235?pdf=render |
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