Protein Arginine Methyltransferases in Neuromuscular Function and Diseases
Neuromuscular diseases (NMDs) are characterized by progressive loss of muscle mass and strength that leads to impaired body movement. It not only severely diminishes the quality of life of the patients, but also subjects them to increased risk of secondary medical conditions such as fall-induced inj...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/3/364 |
| _version_ | 1797488578745335808 |
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| author | Jinwoo Lee Subin An Sang-Jin Lee Jong-Sun Kang |
| author_facet | Jinwoo Lee Subin An Sang-Jin Lee Jong-Sun Kang |
| author_sort | Jinwoo Lee |
| collection | DOAJ |
| description | Neuromuscular diseases (NMDs) are characterized by progressive loss of muscle mass and strength that leads to impaired body movement. It not only severely diminishes the quality of life of the patients, but also subjects them to increased risk of secondary medical conditions such as fall-induced injuries and various chronic diseases. However, no effective treatment is currently available to prevent or reverse the disease progression. Protein arginine methyltransferases (PRMTs) are emerging as a potential therapeutic target for diverse diseases, such as cancer and cardiovascular diseases. Their expression levels are altered in the patients and molecular mechanisms underlying the association between PRMTs and the diseases are being investigated. PRMTs have been shown to regulate development, homeostasis, and regeneration of both muscle and neurons, and their association to NMDs are emerging as well. Through inhibition of PRMT activities, a few studies have reported suppression of cytotoxic phenotypes observed in NMDs. Here, we review our current understanding of PRMTs’ involvement in the pathophysiology of NMDs and potential therapeutic strategies targeting PRMTs to address the unmet medical need. |
| first_indexed | 2024-03-10T00:04:18Z |
| format | Article |
| id | doaj.art-6b28b2de6f51409bba5c51142edc0ff7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T00:04:18Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6b28b2de6f51409bba5c51142edc0ff72023-11-23T16:10:40ZengMDPI AGCells2073-44092022-01-0111336410.3390/cells11030364Protein Arginine Methyltransferases in Neuromuscular Function and DiseasesJinwoo Lee0Subin An1Sang-Jin Lee2Jong-Sun Kang3Research Institute for Aging-Related Diseases, AniMusCure Inc., Suwon 16419, KoreaDepartment of Molecular Cell Biology, School of Medicine, Sungkyunkwan University, Suwon 16419, KoreaResearch Institute for Aging-Related Diseases, AniMusCure Inc., Suwon 16419, KoreaDepartment of Molecular Cell Biology, School of Medicine, Sungkyunkwan University, Suwon 16419, KoreaNeuromuscular diseases (NMDs) are characterized by progressive loss of muscle mass and strength that leads to impaired body movement. It not only severely diminishes the quality of life of the patients, but also subjects them to increased risk of secondary medical conditions such as fall-induced injuries and various chronic diseases. However, no effective treatment is currently available to prevent or reverse the disease progression. Protein arginine methyltransferases (PRMTs) are emerging as a potential therapeutic target for diverse diseases, such as cancer and cardiovascular diseases. Their expression levels are altered in the patients and molecular mechanisms underlying the association between PRMTs and the diseases are being investigated. PRMTs have been shown to regulate development, homeostasis, and regeneration of both muscle and neurons, and their association to NMDs are emerging as well. Through inhibition of PRMT activities, a few studies have reported suppression of cytotoxic phenotypes observed in NMDs. Here, we review our current understanding of PRMTs’ involvement in the pathophysiology of NMDs and potential therapeutic strategies targeting PRMTs to address the unmet medical need.https://www.mdpi.com/2073-4409/11/3/364PRMTneuromuscular diseasesALSmuscle atrophy |
| spellingShingle | Jinwoo Lee Subin An Sang-Jin Lee Jong-Sun Kang Protein Arginine Methyltransferases in Neuromuscular Function and Diseases Cells PRMT neuromuscular diseases ALS muscle atrophy |
| title | Protein Arginine Methyltransferases in Neuromuscular Function and Diseases |
| title_full | Protein Arginine Methyltransferases in Neuromuscular Function and Diseases |
| title_fullStr | Protein Arginine Methyltransferases in Neuromuscular Function and Diseases |
| title_full_unstemmed | Protein Arginine Methyltransferases in Neuromuscular Function and Diseases |
| title_short | Protein Arginine Methyltransferases in Neuromuscular Function and Diseases |
| title_sort | protein arginine methyltransferases in neuromuscular function and diseases |
| topic | PRMT neuromuscular diseases ALS muscle atrophy |
| url | https://www.mdpi.com/2073-4409/11/3/364 |
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