Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women
Objective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorph...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2020.1855192 |
| _version_ | 1797681518594752512 |
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| author | Sahra Esmkhani Hossein Sadeghi Majid Ghasemian Reihaneh Pirjani Mona Amin-Beidokhti Milad Gholami Fakhrolmolouk Yassaee Reza Mirfakhraie |
| author_facet | Sahra Esmkhani Hossein Sadeghi Majid Ghasemian Reihaneh Pirjani Mona Amin-Beidokhti Milad Gholami Fakhrolmolouk Yassaee Reza Mirfakhraie |
| author_sort | Sahra Esmkhani |
| collection | DOAJ |
| description | Objective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30–7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51–13.42, P < 0.0001; respectively). Conclusion: This study confirmed the association of HOTAIR rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings. |
| first_indexed | 2024-03-11T23:47:04Z |
| format | Article |
| id | doaj.art-6b29d172552f4c4a9278512748ca5d17 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:47:04Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-6b29d172552f4c4a9278512748ca5d172023-09-19T09:24:43ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652021-01-01401293510.1080/10641955.2020.18551921855192Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian womenSahra Esmkhani0Hossein Sadeghi1Majid Ghasemian2Reihaneh Pirjani3Mona Amin-Beidokhti4Milad Gholami5Fakhrolmolouk Yassaee6Reza Mirfakhraie7Shahid Beheshti University of Medical SciencesShahid Beheshti University of Medical SciencesShahid Beheshti University of Medical SciencesTehran University of Medical SciencesShahid Beheshti University of Medical SciencesArak University of Medical SciencesShahid Beheshti University of Medical SciencesShahid Beheshti University of Medical SciencesObjective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30–7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51–13.42, P < 0.0001; respectively). Conclusion: This study confirmed the association of HOTAIR rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings.http://dx.doi.org/10.1080/10641955.2020.1855192preeclampsiahotairgenetic association studysingle nucleotide polymorphismlong noncoding-rna |
| spellingShingle | Sahra Esmkhani Hossein Sadeghi Majid Ghasemian Reihaneh Pirjani Mona Amin-Beidokhti Milad Gholami Fakhrolmolouk Yassaee Reza Mirfakhraie Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women Hypertension in Pregnancy preeclampsia hotair genetic association study single nucleotide polymorphism long noncoding-rna |
| title | Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women |
| title_full | Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women |
| title_fullStr | Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women |
| title_full_unstemmed | Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women |
| title_short | Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women |
| title_sort | contribution of long noncoding rna hotair variants to preeclampsia susceptibility in iranian women |
| topic | preeclampsia hotair genetic association study single nucleotide polymorphism long noncoding-rna |
| url | http://dx.doi.org/10.1080/10641955.2020.1855192 |
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