Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses

Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses

Remifentanil (REM) and fentanyl (FEN) are commonly used analgesics that act by activating a µ-opioid receptor (MOR). Although optimal concentrations of REM can be easily maintained during surgery, it is sometimes switched to FEN for optimal pain regulation. However, standards for this switching prot...

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Bibliographic Details
Main Authors: Eiko Uezono, Yusuke Mizobuchi, Kanako Miyano, Katsuya Ohbuchi, Hiroaki Murata, Akane Komatsu, Sei Manabe, Miki Nonaka, Takatsugu Hirokawa, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida, Izumi Kawagoe
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
remifentanil
fentanyl
opioid receptor
desensitization
in silico simulation
Online Access:https://www.mdpi.com/1422-0067/24/9/8369

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