Eye movement control during visual pursuit in Parkinson’s disease
Background Prior studies of oculomotor function in Parkinson’s disease (PD) have either focused on saccades without considering smooth pursuit, or tested smooth pursuit while excluding saccades. The present study investigated the control of saccadic eye movements during pursuit tasksand assessed the...
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PeerJ Inc.
2018-08-01
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| author | Chia-Chien Wu Bo Cao Veena Dali Celia Gagliardi Olivier J. Barthelemy Robert D. Salazar Marc Pomplun Alice Cronin-Golomb Arash Yazdanbakhsh |
| author_facet | Chia-Chien Wu Bo Cao Veena Dali Celia Gagliardi Olivier J. Barthelemy Robert D. Salazar Marc Pomplun Alice Cronin-Golomb Arash Yazdanbakhsh |
| author_sort | Chia-Chien Wu |
| collection | DOAJ |
| description | Background Prior studies of oculomotor function in Parkinson’s disease (PD) have either focused on saccades without considering smooth pursuit, or tested smooth pursuit while excluding saccades. The present study investigated the control of saccadic eye movements during pursuit tasksand assessed the quality of binocular coordinationas potential sensitive markers of PD. Methods Observers fixated on a central cross while a target moved toward it. Once the target reached the fixation cross, observers began to pursue the moving target. To further investigate binocular coordination, the moving target was presented on both eyes (binocular condition), or on one eye only (dichoptic condition). Results The PD group made more saccades than age-matched normal control adults (NC) both during fixation and pursuit. The difference between left and right gaze positions increased over time during the pursuit period for PD but not for NC. The findings were not related to age, as NC and young-adult control group (YC) performed similarly on most of the eye movement measures, and were not correlated with classical measures of PD severity (e.g., Unified Parkinson’s Disease Rating Scale (UPDRS) score). Discussion Our results suggest that PD may be associated with impairment not only in saccade inhibition, but also in binocular coordination during pursuit, and these aspects of dysfunction may be useful in PD diagnosis or tracking of disease course. |
| first_indexed | 2024-03-09T07:03:14Z |
| format | Article |
| id | doaj.art-6b2b83db88224e2381cb6297a865a1c8 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:03:14Z |
| publishDate | 2018-08-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-6b2b83db88224e2381cb6297a865a1c82023-12-03T09:46:18ZengPeerJ Inc.PeerJ2167-83592018-08-016e544210.7717/peerj.5442Eye movement control during visual pursuit in Parkinson’s diseaseChia-Chien Wu0Bo Cao1Veena Dali2Celia Gagliardi3Olivier J. Barthelemy4Robert D. Salazar5Marc Pomplun6Alice Cronin-Golomb7Arash Yazdanbakhsh8Center for Computational Neuroscience and Neural Technology, Boston University, Boston, MA, USADepartment of Psychiatry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, CanadaCenter for Computational Neuroscience and Neural Technology, Boston University, Boston, MA, USACenter for Computational Neuroscience and Neural Technology, Boston University, Boston, MA, USADepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USADepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USADepartment of Computer Science, University of Massachusetts at Boston, Boston, MA, USADepartment of Psychological and Brain Sciences, Boston University, Boston, MA, USACenter for Computational Neuroscience and Neural Technology, Boston University, Boston, MA, USABackground Prior studies of oculomotor function in Parkinson’s disease (PD) have either focused on saccades without considering smooth pursuit, or tested smooth pursuit while excluding saccades. The present study investigated the control of saccadic eye movements during pursuit tasksand assessed the quality of binocular coordinationas potential sensitive markers of PD. Methods Observers fixated on a central cross while a target moved toward it. Once the target reached the fixation cross, observers began to pursue the moving target. To further investigate binocular coordination, the moving target was presented on both eyes (binocular condition), or on one eye only (dichoptic condition). Results The PD group made more saccades than age-matched normal control adults (NC) both during fixation and pursuit. The difference between left and right gaze positions increased over time during the pursuit period for PD but not for NC. The findings were not related to age, as NC and young-adult control group (YC) performed similarly on most of the eye movement measures, and were not correlated with classical measures of PD severity (e.g., Unified Parkinson’s Disease Rating Scale (UPDRS) score). Discussion Our results suggest that PD may be associated with impairment not only in saccade inhibition, but also in binocular coordination during pursuit, and these aspects of dysfunction may be useful in PD diagnosis or tracking of disease course.https://peerj.com/articles/5442.pdfParkinson’s diseaseDichopticPursuitEye movementsSaccadeBinocular |
| spellingShingle | Chia-Chien Wu Bo Cao Veena Dali Celia Gagliardi Olivier J. Barthelemy Robert D. Salazar Marc Pomplun Alice Cronin-Golomb Arash Yazdanbakhsh Eye movement control during visual pursuit in Parkinson’s disease PeerJ Parkinson’s disease Dichoptic Pursuit Eye movements Saccade Binocular |
| title | Eye movement control during visual pursuit in Parkinson’s disease |
| title_full | Eye movement control during visual pursuit in Parkinson’s disease |
| title_fullStr | Eye movement control during visual pursuit in Parkinson’s disease |
| title_full_unstemmed | Eye movement control during visual pursuit in Parkinson’s disease |
| title_short | Eye movement control during visual pursuit in Parkinson’s disease |
| title_sort | eye movement control during visual pursuit in parkinson s disease |
| topic | Parkinson’s disease Dichoptic Pursuit Eye movements Saccade Binocular |
| url | https://peerj.com/articles/5442.pdf |
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