Seroprevalence of hepatitis E virus (<i>Hepeviridae: Orthohepevirus: Orthohepevirus A</i>) among pregnant women in the highly endemic region of Kyrgyzstan
Introduction. Hepatitis E (HE) is an important public health problem worldwide and is especially significant for pregnant women, among whom the associated mortality rate reaches 25%. The distribution of HE serological markers in this cohort in the endemic regions of Central Asia is poorly understood...
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Central Research Institute for Epidemiology
2020-09-01
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| Series: | Вопросы вирусологии |
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| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/409/271 |
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| author | G. I. Alatortseva Z. Bakirova L. N. Lukhverchik A. Z. Nurmatov Z. S. Nurmatov K. E. Tashov L. N. Nesterenko Е. Yu. Malinnikova O. T. Kasymov M. I. Mikhailov V. V. Zverev |
| author_facet | G. I. Alatortseva Z. Bakirova L. N. Lukhverchik A. Z. Nurmatov Z. S. Nurmatov K. E. Tashov L. N. Nesterenko Е. Yu. Malinnikova O. T. Kasymov M. I. Mikhailov V. V. Zverev |
| author_sort | G. I. Alatortseva |
| collection | DOAJ |
| description | Introduction. Hepatitis E (HE) is an important public health problem worldwide and is especially significant for pregnant women, among whom the associated mortality rate reaches 25%. The distribution of HE serological markers in this cohort in the endemic regions of Central Asia is poorly understood. The aim of the study was to assess the seroprevalence of HEV among pregnant women in the region of Kyrgyzstan where an increased incidence of HE is reported.
Material and methods. Blood serum of pregnant women, obtained from medical institutions in Bishkek, city of Osh and Osh region in the period from September 2016 to October 2019, and the control group of clinically healthy women were tested using the test systems “DS-IFA-ANTI-HEV-G” and “DS-IFA-ANTI-HEV-M” (NPO “Diagnostic Systems”, Russia).
Results. IgG antibodies to HEV were detected in 87 (5.9%) of 1472 examined pregnant women, IgM antibodies -in 64 (4.8%) of 1378, while 5 (0.34%) samples were simultaneously positive for IgG and IgM antibodies. The rates of detection of antibodies to HEV in women of three age categories from 17 to 36 years old in the studied and control groups were similar. The analysis of the seasonal dynamics of HEV seroprevalence in pregnant women in the period from February to September 2019 showed a tendency towards an increase in the values of the positivity coefficient of specific IgM antibodies by the beginning of the autumn. Antibodies to HEV were detected with highest frequency in women from Osh region.
Conclusions. A high risk of HEV infection for pregnant women in the surveyed region had been shown. |
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| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:08:43Z |
| publishDate | 2020-09-01 |
| publisher | Central Research Institute for Epidemiology |
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| series | Вопросы вирусологии |
| spelling | doaj.art-6b2ca71a72ea496bb33fc42c0ed4f60a2023-07-12T19:57:33ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972020-09-0165421822710.36233/0507-4088-2020-65-4-218-227346Seroprevalence of hepatitis E virus (<i>Hepeviridae: Orthohepevirus: Orthohepevirus A</i>) among pregnant women in the highly endemic region of KyrgyzstanG. I. Alatortseva0https://orcid.org/0000-0001-9887-4061Z. Bakirova1https://orcid.org/0000-0002-5626-4940L. N. Lukhverchik2https://orcid.org/0000-0002-2997-8892A. Z. Nurmatov3https://orcid.org/0000-0003-3481-227XZ. S. Nurmatov4https://orcid.org/0000-0002-0717-4172K. E. Tashov5https://orcid.org/0000-0002-3059-3834L. N. Nesterenko6https://orcid.org/0000-0002-3825-3906Е. Yu. Malinnikova7https://orcid.org/0000-0002-5501-5707O. T. Kasymov8https://orcid.org/0000-0002-3304-7409M. I. Mikhailov9https://orcid.org/0000-0002-6636-6801V. V. Zverev10https://orcid.org/0000-0002-0017-1892I.I. Mechnikov Research Institute of Vaccines and SeraOsh Center for Disease Prevention and State Sanitary and Epidemiological SurveillanceI.I. Mechnikov Research Institute of Vaccines and SeraScientific Production Association «Preventive Medicine» Ministry of Health of the Kyrgyz RepublicScientific Production Association «Preventive Medicine» Ministry of Health of the Kyrgyz RepublicOsh Interregional Joint Clinical HospitalI.I. Mechnikov Research Institute of Vaccines and SeraI.I. Mechnikov Research Institute of Vaccines and SeraScientific Production Association «Preventive Medicine» Ministry of Health of the Kyrgyz RepublicI.I. Mechnikov Research Institute of Vaccines and SeraI.I. Mechnikov Research Institute of Vaccines and SeraIntroduction. Hepatitis E (HE) is an important public health problem worldwide and is especially significant for pregnant women, among whom the associated mortality rate reaches 25%. The distribution of HE serological markers in this cohort in the endemic regions of Central Asia is poorly understood. The aim of the study was to assess the seroprevalence of HEV among pregnant women in the region of Kyrgyzstan where an increased incidence of HE is reported. Material and methods. Blood serum of pregnant women, obtained from medical institutions in Bishkek, city of Osh and Osh region in the period from September 2016 to October 2019, and the control group of clinically healthy women were tested using the test systems “DS-IFA-ANTI-HEV-G” and “DS-IFA-ANTI-HEV-M” (NPO “Diagnostic Systems”, Russia). Results. IgG antibodies to HEV were detected in 87 (5.9%) of 1472 examined pregnant women, IgM antibodies -in 64 (4.8%) of 1378, while 5 (0.34%) samples were simultaneously positive for IgG and IgM antibodies. The rates of detection of antibodies to HEV in women of three age categories from 17 to 36 years old in the studied and control groups were similar. The analysis of the seasonal dynamics of HEV seroprevalence in pregnant women in the period from February to September 2019 showed a tendency towards an increase in the values of the positivity coefficient of specific IgM antibodies by the beginning of the autumn. Antibodies to HEV were detected with highest frequency in women from Osh region. Conclusions. A high risk of HEV infection for pregnant women in the surveyed region had been shown.https://virusjour.crie.ru/jour/article/viewFile/409/271hepatitis ehepatitis e virusseroepidemiologyseroprevalenceantibodiespregnant |
| spellingShingle | G. I. Alatortseva Z. Bakirova L. N. Lukhverchik A. Z. Nurmatov Z. S. Nurmatov K. E. Tashov L. N. Nesterenko Е. Yu. Malinnikova O. T. Kasymov M. I. Mikhailov V. V. Zverev Seroprevalence of hepatitis E virus (<i>Hepeviridae: Orthohepevirus: Orthohepevirus A</i>) among pregnant women in the highly endemic region of Kyrgyzstan Вопросы вирусологии hepatitis e hepatitis e virus seroepidemiology seroprevalence antibodies pregnant |
| title | Seroprevalence of hepatitis E virus (<i>Hepeviridae: Orthohepevirus: Orthohepevirus A</i>) among pregnant women in the highly endemic region of Kyrgyzstan |
| title_full | Seroprevalence of hepatitis E virus (<i>Hepeviridae: Orthohepevirus: Orthohepevirus A</i>) among pregnant women in the highly endemic region of Kyrgyzstan |
| title_fullStr | Seroprevalence of hepatitis E virus (<i>Hepeviridae: Orthohepevirus: Orthohepevirus A</i>) among pregnant women in the highly endemic region of Kyrgyzstan |
| title_full_unstemmed | Seroprevalence of hepatitis E virus (<i>Hepeviridae: Orthohepevirus: Orthohepevirus A</i>) among pregnant women in the highly endemic region of Kyrgyzstan |
| title_short | Seroprevalence of hepatitis E virus (<i>Hepeviridae: Orthohepevirus: Orthohepevirus A</i>) among pregnant women in the highly endemic region of Kyrgyzstan |
| title_sort | seroprevalence of hepatitis e virus i hepeviridae orthohepevirus orthohepevirus a i among pregnant women in the highly endemic region of kyrgyzstan |
| topic | hepatitis e hepatitis e virus seroepidemiology seroprevalence antibodies pregnant |
| url | https://virusjour.crie.ru/jour/article/viewFile/409/271 |
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