Homocysteine and recurrent miscarriage
Background: It is known that etiological structure of recurrent miscarriage has genetic, anatomical, infectious and immunological factors; however, the cause of recurrent miscarriage in 50-60% of cases is not completely clear. Homocysteine is a sulfur-containing intermediate product in the normal me...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Scientific Medical Association of Moldova
2017-02-01
|
| Series: | The Moldovan Medical Journal |
| Subjects: | |
| Online Access: | http://moldmedjournal.md/wp-content/uploads/2018/10/moldmedjournal-2018-601-visternicean-full-article.pdf |
| _version_ | 1818322868982775808 |
|---|---|
| author | Elena Visternicean |
| author_facet | Elena Visternicean |
| author_sort | Elena Visternicean |
| collection | DOAJ |
| description | Background: It is known that etiological structure of recurrent miscarriage has genetic, anatomical, infectious and immunological factors; however, the cause of recurrent miscarriage in 50-60% of cases is not completely clear. Homocysteine is a sulfur-containing intermediate product in the normal metabolism of methionine. Development mechanisms of vascular complications of hyperhomocysteinemia are currently being intensively studied. Hyperhomocysteinemia affects a number of mechanisms involved in thrombogenesis including coagulation cascade, vessel-thrombocytic section, oxidation-reduction reactions, endothelium, and vascular smooth muscle cells and is associated with an increased risk of adverse outcomes in pregnancy. Materials and methods: The study included 50 women who had experienced the loss of at least two consecutive pregnancies. The level of the total serum homocysteine was measured via the chemiluminescent method. Results: We found that plasma homocysteine concentration < 10 μmol/l was found in 16 patients (32,0%, 95% CI 19,07 – 44,93), 9 patients (18.0%, 95% CI 7,36 – 28,64) had a fasting plasma homocysteine between 10 μmol/l to 12 μmol/l and 25 patients (50.0%, 95%CI 36,15 – 63,85) had significantly high total serum homocysteine values. Among them, 23 patients (46.0%, 95%CI 32,19 – 59,81) had the concentration between 12 – 30 μmol/l and 2 patients (4,0%, 95%CI -1,43 – 9,43) had the concentration > 30μmol/l. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception. In the current study, 40 women (80.0%, 95% CI 68,92 – 91,08) have become pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy. Conclusions: The prevalence of hyperhomocysteinemia was more in unexplained primary early recurrent miscarriages. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception and 40 women (80.0%, 95% CI 68,92 – 91,08) became pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy. |
| first_indexed | 2024-12-13T11:03:39Z |
| format | Article |
| id | doaj.art-6b2d2161b87f4591a56decf62715bb34 |
| institution | Directory Open Access Journal |
| issn | 2537-6373 2537-6381 |
| language | English |
| last_indexed | 2024-12-13T11:03:39Z |
| publishDate | 2017-02-01 |
| publisher | Scientific Medical Association of Moldova |
| record_format | Article |
| series | The Moldovan Medical Journal |
| spelling | doaj.art-6b2d2161b87f4591a56decf62715bb342022-12-21T23:49:09ZengScientific Medical Association of MoldovaThe Moldovan Medical Journal2537-63732537-63812017-02-01601151910.5281/zenodo.1050325Homocysteine and recurrent miscarriageElena Visternicean0Department of Obstetrics and Gynecology No 2, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: It is known that etiological structure of recurrent miscarriage has genetic, anatomical, infectious and immunological factors; however, the cause of recurrent miscarriage in 50-60% of cases is not completely clear. Homocysteine is a sulfur-containing intermediate product in the normal metabolism of methionine. Development mechanisms of vascular complications of hyperhomocysteinemia are currently being intensively studied. Hyperhomocysteinemia affects a number of mechanisms involved in thrombogenesis including coagulation cascade, vessel-thrombocytic section, oxidation-reduction reactions, endothelium, and vascular smooth muscle cells and is associated with an increased risk of adverse outcomes in pregnancy. Materials and methods: The study included 50 women who had experienced the loss of at least two consecutive pregnancies. The level of the total serum homocysteine was measured via the chemiluminescent method. Results: We found that plasma homocysteine concentration < 10 μmol/l was found in 16 patients (32,0%, 95% CI 19,07 – 44,93), 9 patients (18.0%, 95% CI 7,36 – 28,64) had a fasting plasma homocysteine between 10 μmol/l to 12 μmol/l and 25 patients (50.0%, 95%CI 36,15 – 63,85) had significantly high total serum homocysteine values. Among them, 23 patients (46.0%, 95%CI 32,19 – 59,81) had the concentration between 12 – 30 μmol/l and 2 patients (4,0%, 95%CI -1,43 – 9,43) had the concentration > 30μmol/l. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception. In the current study, 40 women (80.0%, 95% CI 68,92 – 91,08) have become pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy. Conclusions: The prevalence of hyperhomocysteinemia was more in unexplained primary early recurrent miscarriages. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception and 40 women (80.0%, 95% CI 68,92 – 91,08) became pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy.http://moldmedjournal.md/wp-content/uploads/2018/10/moldmedjournal-2018-601-visternicean-full-article.pdfhomocysteinespontaneous abortionrecurrent abortionvitamin B supplementation |
| spellingShingle | Elena Visternicean Homocysteine and recurrent miscarriage The Moldovan Medical Journal homocysteine spontaneous abortion recurrent abortion vitamin B supplementation |
| title | Homocysteine and recurrent miscarriage |
| title_full | Homocysteine and recurrent miscarriage |
| title_fullStr | Homocysteine and recurrent miscarriage |
| title_full_unstemmed | Homocysteine and recurrent miscarriage |
| title_short | Homocysteine and recurrent miscarriage |
| title_sort | homocysteine and recurrent miscarriage |
| topic | homocysteine spontaneous abortion recurrent abortion vitamin B supplementation |
| url | http://moldmedjournal.md/wp-content/uploads/2018/10/moldmedjournal-2018-601-visternicean-full-article.pdf |
| work_keys_str_mv | AT elenavisternicean homocysteineandrecurrentmiscarriage |