5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro

5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro

The oligomer of β-amyloid (Aβ) is considered the main neurotoxin in Alzheimer’s disease (AD). Therefore, the inhibition of the formation of Aβ oligomer could be a target for AD therapy. In this study, with the help of the dot blotting assay and transmission electronic microscopy, it was have discove...

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Bibliographic Details
Main Authors: Jiaying Zhao, Fufeng Liu, Chunhui Huang, Jieyi Shentu, Minjun Wang, Chenkai Sun, Liping Chen, Sicheng Yan, Fang Fang, Yuanyuan Wang, Shujun Xu, C. Benjamin Naman, Qinwen Wang, Shan He, Wei Cui
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Molecules
Subjects:
5-hydroxycyclopenicillone
β-amyloid
Alzheimer’s disease
sponge-associated fungus
oligomer
Online Access:https://www.mdpi.com/1420-3049/22/10/1651

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