New stroke prognostic factors
Abstract Background Understanding ischemic stroke pathogenesis helps in prevention, prognosis, and treatment. Stroke is greatly related to inflammation and thrombo-genesis as inflammatory cells (as neutrophils-lymphocytes) and thrombo-genic agents as von Willebrand factor antigen (VWF: Ag) and epica...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-06-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s41983-020-00193-0 |
| _version_ | 1819202602767745024 |
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| author | Wafeek M. Elsheikh Ibrahim E. Alahmar Gelan Mahmoud Salem Eman S. Matar |
| author_facet | Wafeek M. Elsheikh Ibrahim E. Alahmar Gelan Mahmoud Salem Eman S. Matar |
| author_sort | Wafeek M. Elsheikh |
| collection | DOAJ |
| description | Abstract Background Understanding ischemic stroke pathogenesis helps in prevention, prognosis, and treatment. Stroke is greatly related to inflammation and thrombo-genesis as inflammatory cells (as neutrophils-lymphocytes) and thrombo-genic agents as von Willebrand factor antigen (VWF: Ag) and epicardial fat. Objectives of the study Evaluation of epicardial fat thickness (EFT), neutrophil/lymphocytic ratio (NLR), and (VWF: Ag) levels as predisposing and prognostic factors of ischemic stroke. Patients and methods Sixty acute ischemic stroke patients were subjected to clinical assessment (Oxford stroke sheet), National Institute Health Stroke Scale: NIHSS), Modified Rankin Scale (MRS), NLR and VWF: Ag levels, transthoracic echo, duplex on carotid and vertebro-basilar arteries, and brain computed tomography (CT). Thirty-five healthy controls matched for age and sex were subjected to the same steps except NIHSS and MRS. Results EFT, NLR, and VWF among patients were significantly higher than control group. NLR ≥ 2 and VWF: Ag were significant risk factors among stroke patients with VWF: Ag had the higher risk than NLR ≥ 2. NLR was a high valid prognostic marker in predicting stroke outcome (MRS) with (optimal cutoff value 2.05) for prediction of primary unfavorable outcome. There was no statistical significance between (MRS) and EFT or VWF: Ag level. Conclusion EFT represents inexpensive and readily available clinical marker that may be useful in estimating risk of ischemic stroke. NLR is non-expensive easy marker for predicting stroke severity and primary unfavorable outcome. High VWF level increases ischemic stroke risk. |
| first_indexed | 2024-12-23T04:06:38Z |
| format | Article |
| id | doaj.art-6b3038fdc3384b889fb002363112c349 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-12-23T04:06:38Z |
| publishDate | 2020-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-6b3038fdc3384b889fb002363112c3492022-12-21T18:00:38ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292020-06-015611910.1186/s41983-020-00193-0New stroke prognostic factorsWafeek M. Elsheikh0Ibrahim E. Alahmar1Gelan Mahmoud Salem2Eman S. Matar3Neuropsychiatry Department, Faculty of Medicine, Menoufiya UniversityNeuropsychiatry Department, Faculty of Medicine, Menoufiya UniversityNeuropsychiatry Department, Faculty of Medicine, Menoufiya UniversityNeuropsychiatry Department, Faculty of Medicine, Menoufiya UniversityAbstract Background Understanding ischemic stroke pathogenesis helps in prevention, prognosis, and treatment. Stroke is greatly related to inflammation and thrombo-genesis as inflammatory cells (as neutrophils-lymphocytes) and thrombo-genic agents as von Willebrand factor antigen (VWF: Ag) and epicardial fat. Objectives of the study Evaluation of epicardial fat thickness (EFT), neutrophil/lymphocytic ratio (NLR), and (VWF: Ag) levels as predisposing and prognostic factors of ischemic stroke. Patients and methods Sixty acute ischemic stroke patients were subjected to clinical assessment (Oxford stroke sheet), National Institute Health Stroke Scale: NIHSS), Modified Rankin Scale (MRS), NLR and VWF: Ag levels, transthoracic echo, duplex on carotid and vertebro-basilar arteries, and brain computed tomography (CT). Thirty-five healthy controls matched for age and sex were subjected to the same steps except NIHSS and MRS. Results EFT, NLR, and VWF among patients were significantly higher than control group. NLR ≥ 2 and VWF: Ag were significant risk factors among stroke patients with VWF: Ag had the higher risk than NLR ≥ 2. NLR was a high valid prognostic marker in predicting stroke outcome (MRS) with (optimal cutoff value 2.05) for prediction of primary unfavorable outcome. There was no statistical significance between (MRS) and EFT or VWF: Ag level. Conclusion EFT represents inexpensive and readily available clinical marker that may be useful in estimating risk of ischemic stroke. NLR is non-expensive easy marker for predicting stroke severity and primary unfavorable outcome. High VWF level increases ischemic stroke risk.http://link.springer.com/article/10.1186/s41983-020-00193-0Ischemic strokeVon Willbrand factorEpicardial fat thicknessneutrophil-lymphocytic ratio |
| spellingShingle | Wafeek M. Elsheikh Ibrahim E. Alahmar Gelan Mahmoud Salem Eman S. Matar New stroke prognostic factors The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Ischemic stroke Von Willbrand factor Epicardial fat thickness neutrophil-lymphocytic ratio |
| title | New stroke prognostic factors |
| title_full | New stroke prognostic factors |
| title_fullStr | New stroke prognostic factors |
| title_full_unstemmed | New stroke prognostic factors |
| title_short | New stroke prognostic factors |
| title_sort | new stroke prognostic factors |
| topic | Ischemic stroke Von Willbrand factor Epicardial fat thickness neutrophil-lymphocytic ratio |
| url | http://link.springer.com/article/10.1186/s41983-020-00193-0 |
| work_keys_str_mv | AT wafeekmelsheikh newstrokeprognosticfactors AT ibrahimealahmar newstrokeprognosticfactors AT gelanmahmoudsalem newstrokeprognosticfactors AT emansmatar newstrokeprognosticfactors |