Comparison of the effectiveness of Martin’s equation, Friedewald’s equation, and a Novel equation in low-density lipoprotein cholesterol estimation
Abstract Low-density-lipoprotein cholesterol (LDL-C) is the main target in atherosclerotic cardiovascular disease (ASCVD). We aimed to validate and compare a new LDL-C estimation equation with other well-known equations. 177,111 samples were analysed from two contemporary population-based cohorts co...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-92625-x |
| _version_ | 1818427336525086720 |
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| author | Youhyun Song Hye Sun Lee Su Jung Baik Soyoung Jeon Donghee Han Su-Yeon Choi Eun Ju Chun Hae-Won Han Sung Hak Park Jidong Sung Hae Ok Jung Ji Won Lee Hyuk-Jae Chang |
| author_facet | Youhyun Song Hye Sun Lee Su Jung Baik Soyoung Jeon Donghee Han Su-Yeon Choi Eun Ju Chun Hae-Won Han Sung Hak Park Jidong Sung Hae Ok Jung Ji Won Lee Hyuk-Jae Chang |
| author_sort | Youhyun Song |
| collection | DOAJ |
| description | Abstract Low-density-lipoprotein cholesterol (LDL-C) is the main target in atherosclerotic cardiovascular disease (ASCVD). We aimed to validate and compare a new LDL-C estimation equation with other well-known equations. 177,111 samples were analysed from two contemporary population-based cohorts comprising asymptomatic Korean adults who underwent medical examinations. Performances of the Friedewald (FLDL), Martin (MLDL), and Sampson (SLDL) equations in estimating direct LDL-C by homogenous assay were assessed by measures of concordance (R2, RMSE, and mean absolute difference). Analyses were performed according to various triglyceride (TG) and/or LDL-C strata. Secondary analyses were conducted within dyslipidaemia populations of each database. MLDL was superior or at least similar to other equations regardless of TG/LDL-C, in both the general and dyslipidaemia populations (RMSE = 11.45/9.20 mg/dL; R2 = 0.88/0.91; vs FLDL: RMSE = 13.66/10.42 mg/dL; R2 = 0.82/0.89; vs SLDL: RMSE = 12.36/9.39 mg/dL; R2 = 0.85/0.91, per Gangnam Severance Hospital Check-up/Korea Initiatives on Coronary Artery Calcification data). MLDL had a slight advantage over SLDL with the lowest MADs across the full spectrum of TG levels, whether divided into severe hyper/non-hyper to moderate hypertriglyceridaemia samples or stratified by 100-mg/dL TG intervals, even up to TG values of 500–600 mg/dL. MLDL may be a readily adoptable and cost-effective alternative to direct LDL-C measurement, irrespective of dyslipidaemia status. In populations with relatively high prevalence of mild-to-moderate hypertriglyceridaemia, Martin’s equation may be optimal for LDL-C and ASCVD risk estimation. |
| first_indexed | 2024-12-14T14:44:07Z |
| format | Article |
| id | doaj.art-6b30f063ef4c4346b575a22f9da68339 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T14:44:07Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6b30f063ef4c4346b575a22f9da683392022-12-21T22:57:20ZengNature PortfolioScientific Reports2045-23222021-06-0111111110.1038/s41598-021-92625-xComparison of the effectiveness of Martin’s equation, Friedewald’s equation, and a Novel equation in low-density lipoprotein cholesterol estimationYouhyun Song0Hye Sun Lee1Su Jung Baik2Soyoung Jeon3Donghee Han4Su-Yeon Choi5Eun Ju Chun6Hae-Won Han7Sung Hak Park8Jidong Sung9Hae Ok Jung10Ji Won Lee11Hyuk-Jae Chang12Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineBiostatistics Collaboration Unit, Yonsei University College of MedicineHealthcare Research Team, Health Promotion Center, Gangnam Severance HospitalBiostatistics Collaboration Unit, Yonsei University College of MedicineDepartment of Imaging and Medicine, Cedars Sinai Medical CenterDivision of Cardiology, Seoul National University Healthcare System Gangnam Center, Seoul National University College of MedicineDepartment of Radiology, Seoul National University Bundang HospitalDepartment of Internal Medicine, Gangnam Heartscan ClinicDepartment of Radiology, Gangnam Heartscan ClinicDivision of Cardiology, Department of Medicine, Sungkyunkwan University School of Medicine, Heart Stroke & Vascular Institute, Samsung Medical CenterDivision of Cardiology, Cardiovascular Center, College of Medicine, Seoul St. Mary’s Hospital, The Catholic University of KoreaDepartment of Family Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDivision of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of MedicineAbstract Low-density-lipoprotein cholesterol (LDL-C) is the main target in atherosclerotic cardiovascular disease (ASCVD). We aimed to validate and compare a new LDL-C estimation equation with other well-known equations. 177,111 samples were analysed from two contemporary population-based cohorts comprising asymptomatic Korean adults who underwent medical examinations. Performances of the Friedewald (FLDL), Martin (MLDL), and Sampson (SLDL) equations in estimating direct LDL-C by homogenous assay were assessed by measures of concordance (R2, RMSE, and mean absolute difference). Analyses were performed according to various triglyceride (TG) and/or LDL-C strata. Secondary analyses were conducted within dyslipidaemia populations of each database. MLDL was superior or at least similar to other equations regardless of TG/LDL-C, in both the general and dyslipidaemia populations (RMSE = 11.45/9.20 mg/dL; R2 = 0.88/0.91; vs FLDL: RMSE = 13.66/10.42 mg/dL; R2 = 0.82/0.89; vs SLDL: RMSE = 12.36/9.39 mg/dL; R2 = 0.85/0.91, per Gangnam Severance Hospital Check-up/Korea Initiatives on Coronary Artery Calcification data). MLDL had a slight advantage over SLDL with the lowest MADs across the full spectrum of TG levels, whether divided into severe hyper/non-hyper to moderate hypertriglyceridaemia samples or stratified by 100-mg/dL TG intervals, even up to TG values of 500–600 mg/dL. MLDL may be a readily adoptable and cost-effective alternative to direct LDL-C measurement, irrespective of dyslipidaemia status. In populations with relatively high prevalence of mild-to-moderate hypertriglyceridaemia, Martin’s equation may be optimal for LDL-C and ASCVD risk estimation.https://doi.org/10.1038/s41598-021-92625-x |
| spellingShingle | Youhyun Song Hye Sun Lee Su Jung Baik Soyoung Jeon Donghee Han Su-Yeon Choi Eun Ju Chun Hae-Won Han Sung Hak Park Jidong Sung Hae Ok Jung Ji Won Lee Hyuk-Jae Chang Comparison of the effectiveness of Martin’s equation, Friedewald’s equation, and a Novel equation in low-density lipoprotein cholesterol estimation Scientific Reports |
| title | Comparison of the effectiveness of Martin’s equation, Friedewald’s equation, and a Novel equation in low-density lipoprotein cholesterol estimation |
| title_full | Comparison of the effectiveness of Martin’s equation, Friedewald’s equation, and a Novel equation in low-density lipoprotein cholesterol estimation |
| title_fullStr | Comparison of the effectiveness of Martin’s equation, Friedewald’s equation, and a Novel equation in low-density lipoprotein cholesterol estimation |
| title_full_unstemmed | Comparison of the effectiveness of Martin’s equation, Friedewald’s equation, and a Novel equation in low-density lipoprotein cholesterol estimation |
| title_short | Comparison of the effectiveness of Martin’s equation, Friedewald’s equation, and a Novel equation in low-density lipoprotein cholesterol estimation |
| title_sort | comparison of the effectiveness of martin s equation friedewald s equation and a novel equation in low density lipoprotein cholesterol estimation |
| url | https://doi.org/10.1038/s41598-021-92625-x |
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