Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin
Central to the impacts of CD4 T cells, both positive in settings of infectious disease and cancer and negative in the settings of autoimmunity and allergy, is their ability to differentiate into distinct effector subsets with specialized functions. The programming required to support such responses...
| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
MDPI AG
2022-10-01
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| Colecção: | Biomolecules |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/2218-273X/12/11/1549 |
| _version_ | 1827647151740551168 |
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| author | Kunal Dhume Brandon Kaye K. Kai McKinstry |
| author_facet | Kunal Dhume Brandon Kaye K. Kai McKinstry |
| author_sort | Kunal Dhume |
| collection | DOAJ |
| description | Central to the impacts of CD4 T cells, both positive in settings of infectious disease and cancer and negative in the settings of autoimmunity and allergy, is their ability to differentiate into distinct effector subsets with specialized functions. The programming required to support such responses is largely dictated by lineage-specifying transcription factors, often called ‘master regulators’. However, it is increasingly clear that many aspects of CD4 T cell immunobiology that can determine the outcomes of disease states involve a broader transcriptional network. Eomesodermin (Eomes) is emerging as an important member of this class of transcription factors. While best studied in CD8 T cells and NK cells, an increasing body of work has focused on impacts of Eomes expression in CD4 T cell responses in an array of different settings. Here, we focus on the varied impacts reported in these studies that, together, indicate the potential of targeting Eomes expression in CD4 T cells as a strategy to improve a variety of clinical outcomes. |
| first_indexed | 2024-03-09T19:15:11Z |
| format | Article |
| id | doaj.art-6b3187ffdb2744e98d7ddde3c0200a42 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T19:15:11Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6b3187ffdb2744e98d7ddde3c0200a422023-11-24T03:52:26ZengMDPI AGBiomolecules2218-273X2022-10-011211154910.3390/biom12111549Regulation of CD4 T Cell Responses by the Transcription Factor EomesoderminKunal Dhume0Brandon Kaye1K. Kai McKinstry2Immunity and Pathogenesis Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 34744, USAImmunity and Pathogenesis Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 34744, USAImmunity and Pathogenesis Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 34744, USACentral to the impacts of CD4 T cells, both positive in settings of infectious disease and cancer and negative in the settings of autoimmunity and allergy, is their ability to differentiate into distinct effector subsets with specialized functions. The programming required to support such responses is largely dictated by lineage-specifying transcription factors, often called ‘master regulators’. However, it is increasingly clear that many aspects of CD4 T cell immunobiology that can determine the outcomes of disease states involve a broader transcriptional network. Eomesodermin (Eomes) is emerging as an important member of this class of transcription factors. While best studied in CD8 T cells and NK cells, an increasing body of work has focused on impacts of Eomes expression in CD4 T cell responses in an array of different settings. Here, we focus on the varied impacts reported in these studies that, together, indicate the potential of targeting Eomes expression in CD4 T cells as a strategy to improve a variety of clinical outcomes.https://www.mdpi.com/2218-273X/12/11/1549CD4 T cellEomesoderminTh subsetscytolytic CD4 T cellTh1Th17 |
| spellingShingle | Kunal Dhume Brandon Kaye K. Kai McKinstry Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin Biomolecules CD4 T cell Eomesodermin Th subsets cytolytic CD4 T cell Th1 Th17 |
| title | Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin |
| title_full | Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin |
| title_fullStr | Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin |
| title_full_unstemmed | Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin |
| title_short | Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin |
| title_sort | regulation of cd4 t cell responses by the transcription factor eomesodermin |
| topic | CD4 T cell Eomesodermin Th subsets cytolytic CD4 T cell Th1 Th17 |
| url | https://www.mdpi.com/2218-273X/12/11/1549 |
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