Non-ischemic Heart Preservation via Hypothermic Cardioplegic Perfusion Induces Immunodepletion of Donor Hearts Resulting in Diminished Graft Infiltration Following Transplantation

Non-ischemic Heart Preservation via Hypothermic Cardioplegic Perfusion Induces Immunodepletion of Donor Hearts Resulting in Diminished Graft Infiltration Following Transplantation

Introduction: Many donor organs contain significant leukocyte reservoirs which upon transplantation activate recipient leukocytes to initiate acute rejection. We aimed to assess whether non-ischemic heart preservation via ex vivo perfusion promotes immunodepletion and alters the inflammatory status...

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Bibliographic Details
Main Authors: William R. Critchley, John P. Stone, Qiuming Liao, Guangqi Qin, Ivar Risnes, Andrew Trafford, Helge Scott, Trygve Sjöberg, Stig Steen, James E. Fildes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
heart transplantation
acute rejection
heart preservation
hypothermic cardioplegic ex vivo heart perfusion
passenger leukocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01621/full

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