Differential Induction of Reactive Oxygen Species and Expression of Antioxidant Enzymes in Human Melanocytes Correlate with Melanin Content: Implications on the Response to Solar UV and Melanoma Susceptibility

Differential Induction of Reactive Oxygen Species and Expression of Antioxidant Enzymes in Human Melanocytes Correlate with Melanin Content: Implications on the Response to Solar UV and Melanoma Susceptibility

Constitutive pigmentation determines the response to sun exposure and the risk for melanoma, an oxidative stress–driven tumor. Using primary cultures of human melanocytes, we compared the effects of constitutive pigmentation on their antioxidant response to solar UV. The quantitation of eumelanin an...

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Bibliographic Details
Main Authors: Parth R. Upadhyay, Renny J. Starner, Viki B. Swope, Kazumasa Wakamatsu, Shosuke Ito, Zalfa A. Abdel-Malek
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Antioxidants
Subjects:
human melanocytes
eumelanin
pheomelanin
solar UV
oxidative stress
melanoma risk
Online Access:https://www.mdpi.com/2076-3921/11/6/1204

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