RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae
Abstract RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-pro...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
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| Series: | Genetics and Molecular Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000100022&lng=en&tlng=en |
| _version_ | 1818363313606623232 |
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| author | Camila Oliveira Helisson Faoro Lysangela Ronalte Alves Samuel Goldenberg |
| author_facet | Camila Oliveira Helisson Faoro Lysangela Ronalte Alves Samuel Goldenberg |
| author_sort | Camila Oliveira |
| collection | DOAJ |
| description | Abstract RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein complexes (mRNPs). Gene expression regulation in trypanosomatids occurs mainly at the post-transcriptional level and RBPs play a key role in all processes. However, the functional characterization of RBPs in Trypanosoma cruzi has been impaired due to the lack of reliable reverse genetic manipulation tools. The comparison of RBPs from Saccharomyces cerevisiae and T. cruzi might allow inferring on the function of these proteins based on the information available for the orthologous RNA-binding proteins from the S. cerevisiae model organism. In this review, we discuss the role of some RBPs from T. cruzi and their homologues in regulating gene expression in yeast. |
| first_indexed | 2024-12-13T21:46:30Z |
| format | Article |
| id | doaj.art-6b38076e0f3c4c0d8961f8f454d2adf8 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-13T21:46:30Z |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-6b38076e0f3c4c0d8961f8f454d2adf82022-12-21T23:30:24ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-4685401223010.1590/1678-4685-gmb-2016-0258S1415-47572017000100022RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiaeCamila OliveiraHelisson FaoroLysangela Ronalte AlvesSamuel GoldenbergAbstract RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein complexes (mRNPs). Gene expression regulation in trypanosomatids occurs mainly at the post-transcriptional level and RBPs play a key role in all processes. However, the functional characterization of RBPs in Trypanosoma cruzi has been impaired due to the lack of reliable reverse genetic manipulation tools. The comparison of RBPs from Saccharomyces cerevisiae and T. cruzi might allow inferring on the function of these proteins based on the information available for the orthologous RNA-binding proteins from the S. cerevisiae model organism. In this review, we discuss the role of some RBPs from T. cruzi and their homologues in regulating gene expression in yeast.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000100022&lng=en&tlng=enRNA-binding proteinsTrypanosoma cruziSaccharomyces cerevisiaegene expression regulation |
| spellingShingle | Camila Oliveira Helisson Faoro Lysangela Ronalte Alves Samuel Goldenberg RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae Genetics and Molecular Biology RNA-binding proteins Trypanosoma cruzi Saccharomyces cerevisiae gene expression regulation |
| title | RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae |
| title_full | RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae |
| title_fullStr | RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae |
| title_full_unstemmed | RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae |
| title_short | RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae |
| title_sort | rna binding proteins and their role in the regulation of gene expression in trypanosoma cruzi and saccharomyces cerevisiae |
| topic | RNA-binding proteins Trypanosoma cruzi Saccharomyces cerevisiae gene expression regulation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000100022&lng=en&tlng=en |
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