HIV-1 RT-Associated RNase H review
HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Ain Shams University
2018-06-01
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| Series: | Archives of Pharmaceutical Sciences Ain Shams University |
| Subjects: | |
| Online Access: | https://aps.journals.ekb.eg/article_18731.html |
| _version_ | 1818661604650123264 |
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| author | Madonna M. A. Mitry Nermin S. Abdou Rabah A. T. Serya |
| author_facet | Madonna M. A. Mitry Nermin S. Abdou Rabah A. T. Serya |
| author_sort | Madonna M. A. Mitry |
| collection | DOAJ |
| description | HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently, successful inhibitors target the polymerase function of HIV-RT. RNase H evolves to be a promising target for anti-HIV drug research. This review describes the compounds reported as HIV-1 RNase H inhibitors. |
| first_indexed | 2024-12-17T04:47:42Z |
| format | Article |
| id | doaj.art-6b39df7a3c2a4f609b78894b4f8b4f93 |
| institution | Directory Open Access Journal |
| issn | 2356-8380 2356-8399 |
| language | English |
| last_indexed | 2024-12-17T04:47:42Z |
| publishDate | 2018-06-01 |
| publisher | Ain Shams University |
| record_format | Article |
| series | Archives of Pharmaceutical Sciences Ain Shams University |
| spelling | doaj.art-6b39df7a3c2a4f609b78894b4f8b4f932022-12-21T22:03:01ZengAin Shams UniversityArchives of Pharmaceutical Sciences Ain Shams University2356-83802356-83992018-06-01212230https://dx.doi.org/10.21608/aps.2018.18731HIV-1 RT-Associated RNase H reviewMadonna M. A. Mitry0Nermin S. Abdou1Rabah A. T. Serya2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, EgyptHIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently, successful inhibitors target the polymerase function of HIV-RT. RNase H evolves to be a promising target for anti-HIV drug research. This review describes the compounds reported as HIV-1 RNase H inhibitors.https://aps.journals.ekb.eg/article_18731.htmlHIV-1ribonuclease Hreverse transcriptasetropoloneHydrazone |
| spellingShingle | Madonna M. A. Mitry Nermin S. Abdou Rabah A. T. Serya HIV-1 RT-Associated RNase H review Archives of Pharmaceutical Sciences Ain Shams University HIV-1 ribonuclease H reverse transcriptase tropolone Hydrazone |
| title | HIV-1 RT-Associated RNase H review |
| title_full | HIV-1 RT-Associated RNase H review |
| title_fullStr | HIV-1 RT-Associated RNase H review |
| title_full_unstemmed | HIV-1 RT-Associated RNase H review |
| title_short | HIV-1 RT-Associated RNase H review |
| title_sort | hiv 1 rt associated rnase h review |
| topic | HIV-1 ribonuclease H reverse transcriptase tropolone Hydrazone |
| url | https://aps.journals.ekb.eg/article_18731.html |
| work_keys_str_mv | AT madonnamamitry hiv1rtassociatedrnasehreview AT nerminsabdou hiv1rtassociatedrnasehreview AT rabahatserya hiv1rtassociatedrnasehreview |