Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke
Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is a recently discovered iron-dependent cell death pathway associated with the accumulation of lethal reactive lipid...
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| Format: | Article |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.577403/full |
| _version_ | 1818189438151294976 |
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| author | Jie Liu Jie Liu Jie Liu Zhen-Ni Guo Zhen-Ni Guo Xiu-Li Yan Shuo Huang Shuo Huang Shuo Huang Jia-Xin Ren Jia-Xin Ren Yun Luo Yun Luo Yun Luo Yi Yang Yi Yang Yi Yang |
| author_facet | Jie Liu Jie Liu Jie Liu Zhen-Ni Guo Zhen-Ni Guo Xiu-Li Yan Shuo Huang Shuo Huang Shuo Huang Jia-Xin Ren Jia-Xin Ren Yun Luo Yun Luo Yun Luo Yi Yang Yi Yang Yi Yang |
| author_sort | Jie Liu |
| collection | DOAJ |
| description | Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is a recently discovered iron-dependent cell death pathway associated with the accumulation of lethal reactive lipid species. In the past few years, an increasing number of studies have suggested the crosstalk between autophagy and ferroptosis. Ischemic stroke is a complex brain disease regulated by several cell death pathways, including autophagy and ferroptosis. However, the potential links between autophagy and ferroptosis in ischemic stroke have not yet been explored. In this review, we briefly overview the mechanisms of ferroptosis and autophagy, as well as their possible connections in ischemic stroke. The elucidation of crosstalk between different cell death pathways may provide insight into new future ischemic stroke therapies. |
| first_indexed | 2024-12-11T23:42:49Z |
| format | Article |
| id | doaj.art-6b3a5c405c6547f1b54a5a519d6a0490 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T23:42:49Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-6b3a5c405c6547f1b54a5a519d6a04902022-12-22T00:45:41ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-10-011410.3389/fncel.2020.577403577403Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic StrokeJie Liu0Jie Liu1Jie Liu2Zhen-Ni Guo3Zhen-Ni Guo4Xiu-Li Yan5Shuo Huang6Shuo Huang7Shuo Huang8Jia-Xin Ren9Jia-Xin Ren10Yun Luo11Yun Luo12Yun Luo13Yi Yang14Yi Yang15Yi Yang16Department of Neurology, Stroke Center & Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Changchun, ChinaChina National Comprehensive Stroke Center, Changchun, ChinaJilin Provincial Key Laboratory of Cerebrovascular Disease, Changchun, ChinaDepartment of Neurology, Stroke Center & Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Changchun, ChinaChina National Comprehensive Stroke Center, Changchun, ChinaDepartment of Neurology, Stroke Center & Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, Stroke Center & Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Changchun, ChinaChina National Comprehensive Stroke Center, Changchun, ChinaJilin Provincial Key Laboratory of Cerebrovascular Disease, Changchun, ChinaDepartment of Neurology, Stroke Center & Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Changchun, ChinaChina National Comprehensive Stroke Center, Changchun, ChinaDepartment of Neurology, Stroke Center & Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Changchun, ChinaChina National Comprehensive Stroke Center, Changchun, ChinaJilin Provincial Key Laboratory of Cerebrovascular Disease, Changchun, ChinaDepartment of Neurology, Stroke Center & Clinical Trial and Research Center for Stroke, The First Hospital of Jilin University, Changchun, ChinaChina National Comprehensive Stroke Center, Changchun, ChinaJilin Provincial Key Laboratory of Cerebrovascular Disease, Changchun, ChinaAutophagy is a conserved process to maintains homeostasis via the degradation of toxic cell contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is a recently discovered iron-dependent cell death pathway associated with the accumulation of lethal reactive lipid species. In the past few years, an increasing number of studies have suggested the crosstalk between autophagy and ferroptosis. Ischemic stroke is a complex brain disease regulated by several cell death pathways, including autophagy and ferroptosis. However, the potential links between autophagy and ferroptosis in ischemic stroke have not yet been explored. In this review, we briefly overview the mechanisms of ferroptosis and autophagy, as well as their possible connections in ischemic stroke. The elucidation of crosstalk between different cell death pathways may provide insight into new future ischemic stroke therapies.https://www.frontiersin.org/article/10.3389/fncel.2020.577403/fullautophagyferroptosiscell deathischemic strokeiron overloadlipid peroxidation |
| spellingShingle | Jie Liu Jie Liu Jie Liu Zhen-Ni Guo Zhen-Ni Guo Xiu-Li Yan Shuo Huang Shuo Huang Shuo Huang Jia-Xin Ren Jia-Xin Ren Yun Luo Yun Luo Yun Luo Yi Yang Yi Yang Yi Yang Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke Frontiers in Cellular Neuroscience autophagy ferroptosis cell death ischemic stroke iron overload lipid peroxidation |
| title | Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke |
| title_full | Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke |
| title_fullStr | Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke |
| title_full_unstemmed | Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke |
| title_short | Crosstalk Between Autophagy and Ferroptosis and Its Putative Role in Ischemic Stroke |
| title_sort | crosstalk between autophagy and ferroptosis and its putative role in ischemic stroke |
| topic | autophagy ferroptosis cell death ischemic stroke iron overload lipid peroxidation |
| url | https://www.frontiersin.org/article/10.3389/fncel.2020.577403/full |
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