Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation

Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation

<p>Abstract</p> <p>Background</p> <p>As a member of the TNF superfamily, TRAIL could induce human tumor cell apoptosis through its cognate death receptors DR4 or DR5, which can induce formation of the death inducing signaling complex (DISC) and activation of the membran...

Descripció completa

Dades bibliogràfiques
Autors principals:	Qiao Chunxia, Hu Meiyun, Guo Leiming, Lv Ming, Lin Zhou, Geng Jing, Lang Xiaoling, Li Xinying, Li Yan, Ma Yuanfang, Feng Jiannan, Shen Beifen
Format:	Article
Idioma:	English
Publicat:	BMC 2012-07-01
Col·lecció:	BMC Immunology
Matèries:	TRAIL Death receptor 5 Monoclonal antibody Apoptosis Breast cancer
Accés en línia:	http://www.biomedcentral.com/1471-2172/13/40

Ítems similars

Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia
per: Min Cui, et al.
Publicat: (2010-08-01)

Blocking TRAIL-DR5 signaling pathway with soluble death receptor 5 fusion protein mitigates radiation-induced injury
per: Danyang Zhao, et al.
Publicat: (2023-05-01)

Strophanthidin Induces Apoptosis of Human Lung Adenocarcinoma Cells by Promoting TRAIL-DR5 Signaling
per: Xiao Tian, et al.
Publicat: (2024-02-01)

Macrophage-like THP-1 Cells Derived from High-Density Cell Culture Are Resistant to TRAIL-Induced Cell Death via Down-Regulation of Death-Receptors DR4 and DR5
per: Yana Vladimirovna Lomovskaya, et al.
Publicat: (2022-01-01)

Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo
per: Xinran Qiao, et al.
Publicat: (2018-07-01)

Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy
per: Agathe Dubuisson, et al.
Publicat: (2017-10-01)

Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
per: Seok Kim, et al.
Publicat: (2018-07-01)

CD25 targeted therapy of chemotherapy resistant leukemic stem cells using DR5 specific TRAIL peptide
per: Jayaprakasam Madhumathi, et al.
Publicat: (2017-03-01)

Targeting Death Receptor 5 (DR5) for the imaging and treatment of primary bone and soft tissue tumors: an update of the literature
per: Zakareya Gamie, et al.
Publicat: (2024-09-01)

Magnolol Enhances the Therapeutic Effects of TRAIL through DR5 Upregulation and Downregulation of c-FLIP and Mcl-1 Proteins in Cancer Cells
per: Seon Min Woo, et al.
Publicat: (2020-10-01)

Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
per: Jeong Mi Yun, et al.
Publicat: (2018-09-01)

Thioridazine Sensitizes Apoptotic Effect of TRAIL in Human Lung Cancer PC9 Cells Through ER Stress Mediated Up-regulation of DR5
per: Juan LI, et al.
Publicat: (2017-02-01)

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP
per: Mi-Yeon Jeon, et al.
Publicat: (2018-11-01)

NK Cells Can Preferentially Target Prostate Cancer Stem-like Cells via the TRAIL/DR5 Signaling Pathway
per: Taiga Seki, et al.
Publicat: (2021-11-01)

Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5
per: de Vries Elisabeth GE, et al.
Publicat: (2011-01-01)

Amphiphilic Poly(<i>N</i>-vinylpyrrolidone) Nanoparticles Conjugated with DR5-Specific Antitumor Cytokine DR5-B for Targeted Delivery to Cancer Cells
per: Anne Yagolovich, et al.
Publicat: (2021-09-01)

Bortezomib promotes the TRAIL-mediated killing of resistant rhabdomyosarcoma by ErbB2/Her2-targeted CAR-NK-92 cells via DR5 upregulation
per: Catrin Heim, et al.
Publicat: (2024-06-01)

DR5‐Cbl‐b/c‐Cbl‐TRAF2 complex inhibits TRAIL‐induced apoptosis by promoting TRAF2‐mediated polyubiquitination of caspase‐8 in gastric cancer cells
per: Ling Xu, et al.
Publicat: (2017-12-01)

Landscape space 5 : walking space
Publicat: ([200)

Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4
per: Ismael Obaidi, et al.
Publicat: (2020-05-01)

First-in-human DR5 PET reveals insufficient DR5 expression in patients with gastrointestinal cancer
per: Feng Wang, et al.
Publicat: (2021-07-01)

Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile
per: Anne V. Yagolovich, et al.
Publicat: (2020-04-01)

Urban trails : a preliminary list of trails and sources/
per: 409605 Goodey, Brian
Publicat: (1974)

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.
per: Mongkolsapaya, J, et al.
Publicat: (1999)

The release of soluble forms of TRAIL and DR5 by neutrophils of oral cavity cancer patients.
per: Magdalena Marcinczyk, et al.
Publicat: (2008-06-01)

Combination of oridonin and TRAIL induces apoptosis in uveal melanoma cells by upregulating DR5
per: Xin Hua, et al.
Publicat: (2021-12-01)

Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of Geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis
per: Khuri Fadlo R, et al.
Publicat: (2010-01-01)

Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL
per: Artem A. Artykov, et al.
Publicat: (2021-09-01)

Planning for urban trails/
per: 8697 American Society of Planning Officials, et al.
Publicat: (1969)

“Wild” Generosity: The Role of Trail Angels in Shaping Community on America’s Long-Distance Hiking Trails
per: Kristi McLeod
Publicat: (2024-07-01)

Corrigendum: Death Receptors DR4 and DR5 Undergo Spontaneous and Ligand-Mediated Endocytosis and Recycling Regardless of the Sensitivity of Cancer Cells to TRAIL
per: Artem A. Artykov, et al.
Publicat: (2022-02-01)

Selective targeting of DR5 circumvents resistance of MG-63 osteosarcoma to trail-induced apoptosis
per: Locklin, R, et al.
Publicat: (2006)

TRAIL/DR5 pathway promotes AKT phosphorylation, skeletal muscle differentiation, and glucose uptake
per: Barbara Toffoli, et al.
Publicat: (2021-11-01)

‘Standing on the Shoulders of the Giants’: Dr. Robert Kyle
per: Mohamad Mohty, et al.
Publicat: (2022-11-01)

Traals for the twenty-first century : planning, design, and managemant manual for multi use-trails /
per: Ryan, Karen-Lee
Publicat: (1993)

Trailing TRAIL Resistance: Novel Targets for TRAIL sensitization in Cancer cells
per: RACHANA eTRIVEDI, et al.
Publicat: (2015-04-01)

OBSERVATIONAL TRAILS IN LIPIDOLOGY
per: S. A. Shalnova
Publicat: (2016-01-01)

Long-lived meteor trails
per: Mikhalev A.V., et al.
Publicat: (2019-09-01)

TRAIL/DR5 signaling promotes macrophage foam cell formation by modulating scavenger receptor expression.
per: Fang Fang Liu, et al.
Publicat: (2014-01-01)

Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
per: Dongjin Jeong, et al.
Publicat: (2021-07-01)