Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation

Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation

<p>Abstract</p> <p>Background</p> <p>As a member of the TNF superfamily, TRAIL could induce human tumor cell apoptosis through its cognate death receptors DR4 or DR5, which can induce formation of the death inducing signaling complex (DISC) and activation of the membran...

Полное описание

Библиографические подробности
Главные авторы:	Qiao Chunxia, Hu Meiyun, Guo Leiming, Lv Ming, Lin Zhou, Geng Jing, Lang Xiaoling, Li Xinying, Li Yan, Ma Yuanfang, Feng Jiannan, Shen Beifen
Формат:	Статья
Язык:	English
Опубликовано:	BMC 2012-07-01
Серии:	BMC Immunology
Предметы:	TRAIL Death receptor 5 Monoclonal antibody Apoptosis Breast cancer
Online-ссылка:	http://www.biomedcentral.com/1471-2172/13/40

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