Association of plasma free triiodothyronine levels with contrast-induced acute kidney injury and short-term survival in patients with acute myocardial infarction
Objective: Post-treatment contrast-induced acute kidney injury (CI-AKI) is associated with poor outcomes in patients with acute myocardial infarction (AMI). A lower free triiodothyronine (FT3) level predicts a poor prognosis of AMI patients. This study evaluated the effect of plasma FT3 level in pre...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-06-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/11/7/EC-22-0120.xml |
| _version_ | 1828194355397001216 |
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| author | Ling Sun Wenwu Zhu Yuan Ji Ailin Zou Lipeng Mao Boyu Chi Jianguang Jiang Xuejun Zhou Qingjie Wang Fengxiang Zhang |
| author_facet | Ling Sun Wenwu Zhu Yuan Ji Ailin Zou Lipeng Mao Boyu Chi Jianguang Jiang Xuejun Zhou Qingjie Wang Fengxiang Zhang |
| author_sort | Ling Sun |
| collection | DOAJ |
| description | Objective: Post-treatment contrast-induced acute kidney injury (CI-AKI) is associated with poor outcomes in patients with acute myocardial infarction (AMI). A lower free triiodothyronine (FT3) level predicts a poor prognosis of AMI patients. This study evaluated the effect of plasma FT3 level in predicting CI-AKI and short-term survival among AMI patients.
Methods: Coronary arteriography or percutaneous coronary intervention was performed in patients with AMI. A 1:3 propensity score (PS) was used to match patients in the CI-AKI group and the non-CI-AKI group.
Results: Of 1480 patients enrolled in the study, 224 (15.1%) patients developed CI-AKI. The FT3 level was lower in CI-AKI patients than in non-CI-AKI patients (3.72 ± 0.88 pmol/L vs 4.01 ± 0.80 pmol/L, P < 0.001). Compared with those at the lowest quartile of FT3, the patients at quartiles 2–4 had a higher risk of CI-AKI respectively (P for trend = 0.005). The risk of CI-AKI increased by 17.7% as FT3 level decreased by one unit after PS-matching analysis (odds ratio: 0.823; 95% CI: 0.685–0.988, P = 0.036). After a median of 31 days of follow-up (interquartile range: 30–35 days), 78 patients died, including 72 cardiogenic deaths and 6 non-cardiogenic deaths, with more deaths in the CI-AKI group than in the non-CI-AKI group (53 vs 25, P < 0.001). Kaplan–Meier survival analysis showed that patients at a lower FT3 quartile achieved a worse survival before and after matching.
Conclusion: Lower FT3 may increase the risk of CI-AKI and 1-month mortality in AMI patients. |
| first_indexed | 2024-04-12T09:24:46Z |
| format | Article |
| id | doaj.art-6b3aff3d88d842d8ae9955384d423e40 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-12T09:24:46Z |
| publishDate | 2022-06-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-6b3aff3d88d842d8ae9955384d423e402022-12-22T03:38:32ZengBioscientificaEndocrine Connections2049-36142022-06-0111719https://doi.org/10.1530/EC-22-0120Association of plasma free triiodothyronine levels with contrast-induced acute kidney injury and short-term survival in patients with acute myocardial infarctionLing Sun0Wenwu Zhu1Yuan Ji2Ailin Zou3Lipeng Mao4Boyu Chi5Jianguang Jiang6Xuejun Zhou7Qingjie Wang8Fengxiang Zhang9Department of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China; Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Cardiology, Xuzhou Central Hospital, Xuzhou Clinical School of Nanjing Medical University, Xuzhou, Jiangsu, ChinaDepartment of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaDepartment of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaDepartment of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China; Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China; Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaDepartment of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaDepartment of Cardiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaSection of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaObjective: Post-treatment contrast-induced acute kidney injury (CI-AKI) is associated with poor outcomes in patients with acute myocardial infarction (AMI). A lower free triiodothyronine (FT3) level predicts a poor prognosis of AMI patients. This study evaluated the effect of plasma FT3 level in predicting CI-AKI and short-term survival among AMI patients. Methods: Coronary arteriography or percutaneous coronary intervention was performed in patients with AMI. A 1:3 propensity score (PS) was used to match patients in the CI-AKI group and the non-CI-AKI group. Results: Of 1480 patients enrolled in the study, 224 (15.1%) patients developed CI-AKI. The FT3 level was lower in CI-AKI patients than in non-CI-AKI patients (3.72 ± 0.88 pmol/L vs 4.01 ± 0.80 pmol/L, P < 0.001). Compared with those at the lowest quartile of FT3, the patients at quartiles 2–4 had a higher risk of CI-AKI respectively (P for trend = 0.005). The risk of CI-AKI increased by 17.7% as FT3 level decreased by one unit after PS-matching analysis (odds ratio: 0.823; 95% CI: 0.685–0.988, P = 0.036). After a median of 31 days of follow-up (interquartile range: 30–35 days), 78 patients died, including 72 cardiogenic deaths and 6 non-cardiogenic deaths, with more deaths in the CI-AKI group than in the non-CI-AKI group (53 vs 25, P < 0.001). Kaplan–Meier survival analysis showed that patients at a lower FT3 quartile achieved a worse survival before and after matching. Conclusion: Lower FT3 may increase the risk of CI-AKI and 1-month mortality in AMI patients.https://ec.bioscientifica.com/view/journals/ec/11/7/EC-22-0120.xmlacute myocardial infarctionfree triiodothyroninecontrast-induced acute kidney injurypropensity score matching analysisshort-term survival |
| spellingShingle | Ling Sun Wenwu Zhu Yuan Ji Ailin Zou Lipeng Mao Boyu Chi Jianguang Jiang Xuejun Zhou Qingjie Wang Fengxiang Zhang Association of plasma free triiodothyronine levels with contrast-induced acute kidney injury and short-term survival in patients with acute myocardial infarction Endocrine Connections acute myocardial infarction free triiodothyronine contrast-induced acute kidney injury propensity score matching analysis short-term survival |
| title | Association of plasma free triiodothyronine levels with contrast-induced acute kidney injury and short-term survival in patients with acute myocardial infarction |
| title_full | Association of plasma free triiodothyronine levels with contrast-induced acute kidney injury and short-term survival in patients with acute myocardial infarction |
| title_fullStr | Association of plasma free triiodothyronine levels with contrast-induced acute kidney injury and short-term survival in patients with acute myocardial infarction |
| title_full_unstemmed | Association of plasma free triiodothyronine levels with contrast-induced acute kidney injury and short-term survival in patients with acute myocardial infarction |
| title_short | Association of plasma free triiodothyronine levels with contrast-induced acute kidney injury and short-term survival in patients with acute myocardial infarction |
| title_sort | association of plasma free triiodothyronine levels with contrast induced acute kidney injury and short term survival in patients with acute myocardial infarction |
| topic | acute myocardial infarction free triiodothyronine contrast-induced acute kidney injury propensity score matching analysis short-term survival |
| url | https://ec.bioscientifica.com/view/journals/ec/11/7/EC-22-0120.xml |
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