Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application
Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons. NDDs threaten the lives of millions of people worldwide and regretfully remain incurable. It is well...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383522001009 |
| _version_ | 1828335495987331072 |
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| author | Jiajia Xu Wei Du Yunhe Zhao Kahleong Lim Li Lu Chengwu Zhang Lin Li |
| author_facet | Jiajia Xu Wei Du Yunhe Zhao Kahleong Lim Li Lu Chengwu Zhang Lin Li |
| author_sort | Jiajia Xu |
| collection | DOAJ |
| description | Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons. NDDs threaten the lives of millions of people worldwide and regretfully remain incurable. It is well accepted that dysfunction of mitochondria underlies the pathogenesis of NDDs. Dysfunction of mitochondria results in energy depletion, oxidative stress, calcium overloading, caspases activation, which dominates the neuronal death of NDDs. Therefore, mitochondria are the preferred target for intervention of NDDs. So far various mitochondria-targeting drugs have been developed and delightfully some of them demonstrate promising outcome, though there are still some obstacles such as targeting specificity, delivery capacity hindering the drugs development. In present review, we will elaborately address 1) the strategy to design mitochondria targeting drugs, 2) the rescue mechanism of respective mitochondria targeting drugs, 3) how to evaluate the therapeutic effect. Hopefully this review will provide comprehensive knowledge for understanding how to develop more effective drugs for the treatment of NDDs. |
| first_indexed | 2024-04-13T21:47:09Z |
| format | Article |
| id | doaj.art-6b3c12bf49a84ee3ab5188c38ffe1253 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-04-13T21:47:09Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-6b3c12bf49a84ee3ab5188c38ffe12532022-12-22T02:28:31ZengElsevierActa Pharmaceutica Sinica B2211-38352022-06-0112627782789Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and applicationJiajia Xu0Wei Du1Yunhe Zhao2Kahleong Lim3Li Lu4Chengwu Zhang5Lin Li6Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), Nanjing 211816, ChinaKey Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), Nanjing 211816, ChinaDepartment of Anatomy, Shanxi Medical University, Taiyuan 030001, ChinaLee Kang Chian School of Medicine, Nanyang Technological University, Singapore 308232, SingaporeDepartment of Anatomy, Shanxi Medical University, Taiyuan 030001, China; Corresponding authors: Tel.: +86 351 4135787, fax: +86 351 2022548 (Li Lu); Tel.: +86 25 83587982, fax: +86 25 83587981 (Chengwu Zhang, Lin Li).Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China; School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China; Corresponding authors: Tel.: +86 351 4135787, fax: +86 351 2022548 (Li Lu); Tel.: +86 25 83587982, fax: +86 25 83587981 (Chengwu Zhang, Lin Li).Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China; The Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen 361005, China; Corresponding authors: Tel.: +86 351 4135787, fax: +86 351 2022548 (Li Lu); Tel.: +86 25 83587982, fax: +86 25 83587981 (Chengwu Zhang, Lin Li).Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons. NDDs threaten the lives of millions of people worldwide and regretfully remain incurable. It is well accepted that dysfunction of mitochondria underlies the pathogenesis of NDDs. Dysfunction of mitochondria results in energy depletion, oxidative stress, calcium overloading, caspases activation, which dominates the neuronal death of NDDs. Therefore, mitochondria are the preferred target for intervention of NDDs. So far various mitochondria-targeting drugs have been developed and delightfully some of them demonstrate promising outcome, though there are still some obstacles such as targeting specificity, delivery capacity hindering the drugs development. In present review, we will elaborately address 1) the strategy to design mitochondria targeting drugs, 2) the rescue mechanism of respective mitochondria targeting drugs, 3) how to evaluate the therapeutic effect. Hopefully this review will provide comprehensive knowledge for understanding how to develop more effective drugs for the treatment of NDDs.http://www.sciencedirect.com/science/article/pii/S2211383522001009Neurodegenerative diseasesMitochondriaTargeting drugApoptosisReactive oxygen speciesAdenosine triphosphate |
| spellingShingle | Jiajia Xu Wei Du Yunhe Zhao Kahleong Lim Li Lu Chengwu Zhang Lin Li Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application Acta Pharmaceutica Sinica B Neurodegenerative diseases Mitochondria Targeting drug Apoptosis Reactive oxygen species Adenosine triphosphate |
| title | Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application |
| title_full | Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application |
| title_fullStr | Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application |
| title_full_unstemmed | Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application |
| title_short | Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application |
| title_sort | mitochondria targeting drugs for neurodegenerative diseases design mechanism and application |
| topic | Neurodegenerative diseases Mitochondria Targeting drug Apoptosis Reactive oxygen species Adenosine triphosphate |
| url | http://www.sciencedirect.com/science/article/pii/S2211383522001009 |
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