Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application

Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application

Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons. NDDs threaten the lives of millions of people worldwide and regretfully remain incurable. It is well...

Full description

Bibliographic Details
Main Authors:	Jiajia Xu, Wei Du, Yunhe Zhao, Kahleong Lim, Li Lu, Chengwu Zhang, Lin Li
Format:	Article
Language:	English
Published:	Elsevier 2022-06-01
Series:	Acta Pharmaceutica Sinica B
Subjects:	Neurodegenerative diseases Mitochondria Targeting drug Apoptosis Reactive oxygen species Adenosine triphosphate
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383522001009

Similar Items

Mitochondria targeting drugs for neurodegenerative diseases - design, mechanism and application
by: Xu, Jiajia, et al.
Published: (2023)

Mitochondria-targeted metallo-drugs against cancer: A current mechanistic perspective
by: Chinmay Pal
Published: (2023-12-01)

Mitochondria as Targets for Endothelial Protection in COVID-19
by: Boris V. Chernyak, et al.
Published: (2020-11-01)

Methylene Blue Reduces Neuronal Apoptosis and Improves Blood-Brain Barrier Integrity After Traumatic Brain Injury
by: Jun Shen, et al.
Published: (2019-11-01)

Do You Remember Mitochondria?
by: Flavia Messina, et al.
Published: (2020-03-01)

Unraveling mitochondria‐targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials
by: Haibao Peng, et al.
Published: (2023-04-01)

Mitochondrial Dysfunction and Oxidative Stress in Asthma: Implications for Mitochondria-Targeted Antioxidant Therapeutics
by: P. Hemachandra Reddy
Published: (2011-02-01)

Sinularin, an Anti-Cancer Agent Causing Mitochondria-Modulated Apoptosis and Cytoskeleton Disruption in Human Hepatocellular Carcinoma
by: Chou-Yuan Ko, et al.
Published: (2021-04-01)

Adenosine thiamine triphosphate and adenosine thiamine triphosphate hydrolase activity in animal tissues
by: A. F. Makarchikov, et al.
Published: (2018-07-01)

The Hidden Notes of Redox Balance in Neurodegenerative Diseases
by: Silvia Piccirillo, et al.
Published: (2022-07-01)

Asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria
by: Tiancong Wu, et al.
Published: (2017-01-01)

Sirtuins and redox signaling interplay in neurogenesis, neurodegenerative diseases, and neural cell reprogramming
by: Elisabetta Mormone, et al.
Published: (2023-02-01)

Isoaaptamine increases ROS levels causing autophagy and mitochondria-mediated apoptosis in glioblastoma multiforme cells
by: Zhi-Hong Wen, et al.
Published: (2023-04-01)

Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review
by: Chisato Fujimoto, et al.
Published: (2019-04-01)

Pardaxin Activates Excessive Mitophagy and Mitochondria-Mediated Apoptosis in Human Ovarian Cancer by Inducing Reactive Oxygen Species
by: Yen-Po Chen, et al.
Published: (2021-11-01)

GENE TRANSFER IN TOBACCO MITOCHONDRIA IN VITRO AND IN VIVO
by: Katyshev A.I., et al.
Published: (2012-08-01)

Lysing Agents for Characteristic Polluting Microorganisms in Jet Fuels
by: Yun Xiong, et al.
Published: (2019-06-01)

Telmisartan induces melanoma cell apoptosis and synergizes with vemurafenib <i>in vitro</i> by altering cell bioenergetics
by: Jelena Grahovac, et al.
Published: (2019-06-01)

Mitochondria’s Role in Skin Ageing
by: Roisin Stout, et al.
Published: (2019-05-01)

Mitochondria-targeted organic sonodynamic therapy agents: concept, benefits, and future directions
by: Eunbin Hwang, et al.
Published: (2023-06-01)

Role of Reactive Oxygen Species-elicited Apoptosis in the Pathophysiology of Mitochondrial and Neurodegenerative Diseases Associated With Mitochondrial DNA Mutations
by: Chun-Yi Liu, et al.
Published: (2009-08-01)

Mitochondria-Targeted Antioxidants and Skeletal Muscle Function
by: Sophie C. Broome, et al.
Published: (2018-08-01)

Iridium (III) complex-loaded liposomes as a drug delivery system for lung cancer through mitochondrial dysfunction
by: Liao C, et al.
Published: (2018-07-01)

Targeting Mitochondrial Dysfunction in Lung Diseases: Emphasis on Mitophagy
by: Sureshbabu eAngara, et al.
Published: (2013-12-01)

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases
by: Jinggong Liu, et al.
Published: (2020-09-01)

Potential oxidative stress related targets of mitochondria-focused therapy of PTSD
by: Hanna Kmita, et al.
Published: (2023-11-01)

Evaluation of bioenergetic and mitochondrial function in liver transplantation
by: Rui Miguel Martins, et al.
Published: (2019-03-01)

Comparing Early Eukaryotic Integration of Mitochondria and Chloroplasts in the Light of Internal ROS Challenges: Timing is of the Essence
by: Dave Speijer, et al.
Published: (2020-06-01)

Role of Mitochondria in Neurodegenerative Diseases: From an Epigenetic Perspective
by: Sutong Xu, et al.
Published: (2021-08-01)

Microglial cell dysregulation in Brain Aging and Neurodegeneration.
by: Rommy eVon Bernhardi, et al.
Published: (2015-07-01)

Necroptosis: Is There a Role for Mitochondria?
by: Kurt eMarshall, et al.
Published: (2014-08-01)

Oxidative stress induced by berberine-based mitochondria-targeted low temperature photothermal therapy
by: Hongzhi Hu, et al.
Published: (2023-02-01)

Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?
by: Alessandra Murabito, et al.
Published: (2020-03-01)

Cáncer y mitocondria: un aspecto central para el desarrollo y crecimiento tumoral
by: Sofía Isabel Freyre-Bernal, et al.
Published: (2017-04-01)

Mitochondria‐targeted nanoparticles in treatment of neurodegenerative diseases
by: Yue Zhang, et al.
Published: (2021-12-01)

Mitochondria-Targeted Antioxidants, an Innovative Class of Antioxidant Compounds for Neurodegenerative Diseases: Perspectives and Limitations
by: Matteo Fields, et al.
Published: (2023-02-01)

Glutathione and Mitochondria
by: Vicent eRibas, et al.
Published: (2014-07-01)

Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe
by: Cristina Panuzzo, et al.
Published: (2020-05-01)

Mitochondria Are Potential Targets for the Development of New Drugs Against Neutrophilic Inflammation in Severe Pneumonia Including COVID-19
by: Nina V. Vorobjeva, et al.
Published: (2021-01-01)

Editorial: Mitochondria, metabolism and cardiovascular diseases
by: Jun-ichiro Koga, et al.
Published: (2022-08-01)