Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study
The renin-angiotensin system (RAS) is a crucial regulator of vascular resistance and blood volume in the body. This study aimed to examine the genetic predisposition of the plasma renin concentration influencing future hypertension incidence. Based on the Korean Genome and Epidemiology Cohort datase...
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MDPI AG
2022-03-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/9/4/104 |
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| author | Sung-Bum Lee Byoungjin Park Kyung-Won Hong Dong-Hyuk Jung |
| author_facet | Sung-Bum Lee Byoungjin Park Kyung-Won Hong Dong-Hyuk Jung |
| author_sort | Sung-Bum Lee |
| collection | DOAJ |
| description | The renin-angiotensin system (RAS) is a crucial regulator of vascular resistance and blood volume in the body. This study aimed to examine the genetic predisposition of the plasma renin concentration influencing future hypertension incidence. Based on the Korean Genome and Epidemiology Cohort dataset, 5211 normotensive individuals at enrollment were observed over 12 years, categorized into the low-renin and high-renin groups. We conducted genome-wide association studies for the total, low-renin, and high-renin groups. Among the significant SNPs, the lead SNPs of each locus were focused on for further interpretation. The effect of genotypes was determined by logistic regression analysis between controls and new-onset hypertension, after adjusting for potential confounding variables. During a mean follow-up period of 7.6 years, 1704 participants (32.7%) developed hypertension. The low-renin group showed more incidence rates of new-onset hypertension (35.3%) than the high-renin group (26.5%). Among 153 SNPs in renin-related gene regions, two SNPs (rs11726091 and rs8137145) showed an association in the high-renin group, four SNPs (rs17038966, rs145286444, rs2118663, and rs12336898) in the low-renin group, and three SNPs (rs1938859, rs7968218, and rs117246401) in the total population. Most significantly, the low-renin SNP rs12336898 in the <i>SPTAN1</i> gene, closely related to vascular wall remodeling, was associated with the development of hypertension (<i>p</i>-value = 1.3 × 10<sup>−6</sup>). We found the candidate genetic polymorphisms according to blood renin concentration. Our results might be a valuable indicator for hypertension risk prediction and preventive measure, considering renin concentration with genetic susceptibility. |
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| language | English |
| last_indexed | 2024-03-09T13:30:10Z |
| publishDate | 2022-03-01 |
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| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-6b3f821734754f66b8ec85e23afec5452023-11-30T21:18:26ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252022-03-019410410.3390/jcdd9040104Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort StudySung-Bum Lee0Byoungjin Park1Kyung-Won Hong2Dong-Hyuk Jung3Severance Check-up, Yonsei University Health System, Yongin-si 16995, KoreaDepartment of Family Medicine, Yongin Severance Hosptal, Yongin-si 16995, KoreaHealthcare R&D Division, Theragen Bio Co., Ltd., Ganggyo-ro 145, Suwon-si 16229, KoreaDepartment of Family Medicine, Yongin Severance Hosptal, Yongin-si 16995, KoreaThe renin-angiotensin system (RAS) is a crucial regulator of vascular resistance and blood volume in the body. This study aimed to examine the genetic predisposition of the plasma renin concentration influencing future hypertension incidence. Based on the Korean Genome and Epidemiology Cohort dataset, 5211 normotensive individuals at enrollment were observed over 12 years, categorized into the low-renin and high-renin groups. We conducted genome-wide association studies for the total, low-renin, and high-renin groups. Among the significant SNPs, the lead SNPs of each locus were focused on for further interpretation. The effect of genotypes was determined by logistic regression analysis between controls and new-onset hypertension, after adjusting for potential confounding variables. During a mean follow-up period of 7.6 years, 1704 participants (32.7%) developed hypertension. The low-renin group showed more incidence rates of new-onset hypertension (35.3%) than the high-renin group (26.5%). Among 153 SNPs in renin-related gene regions, two SNPs (rs11726091 and rs8137145) showed an association in the high-renin group, four SNPs (rs17038966, rs145286444, rs2118663, and rs12336898) in the low-renin group, and three SNPs (rs1938859, rs7968218, and rs117246401) in the total population. Most significantly, the low-renin SNP rs12336898 in the <i>SPTAN1</i> gene, closely related to vascular wall remodeling, was associated with the development of hypertension (<i>p</i>-value = 1.3 × 10<sup>−6</sup>). We found the candidate genetic polymorphisms according to blood renin concentration. Our results might be a valuable indicator for hypertension risk prediction and preventive measure, considering renin concentration with genetic susceptibility.https://www.mdpi.com/2308-3425/9/4/104hypertensionreningenome-wide association studycohort studyKoreans |
| spellingShingle | Sung-Bum Lee Byoungjin Park Kyung-Won Hong Dong-Hyuk Jung Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study Journal of Cardiovascular Development and Disease hypertension renin genome-wide association study cohort study Koreans |
| title | Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study |
| title_full | Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study |
| title_fullStr | Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study |
| title_full_unstemmed | Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study |
| title_short | Genome-Wide Association of New-Onset Hypertension According to Renin Concentration: The Korean Genome and Epidemiology Cohort Study |
| title_sort | genome wide association of new onset hypertension according to renin concentration the korean genome and epidemiology cohort study |
| topic | hypertension renin genome-wide association study cohort study Koreans |
| url | https://www.mdpi.com/2308-3425/9/4/104 |
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