To study the planned surgical procedure in single-dose antibiotic prophylaxis
Background: Postoperative wound infection may be due to many causes, of which “microbial contamination” is the factor that is influenced by antibiotic administration. Since the concept of antimicrobial prophylaxis has emerged, several workers have searched for optimal antimicrobial drugs, their rout...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2023-12-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/57680 |
| _version_ | 1797431012902305792 |
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| author | Chandrakala Dutt Dutt RD Tarushi Dutt Jayendra Arya |
| author_facet | Chandrakala Dutt Dutt RD Tarushi Dutt Jayendra Arya |
| author_sort | Chandrakala Dutt |
| collection | DOAJ |
| description | Background: Postoperative wound infection may be due to many causes, of which “microbial contamination” is the factor that is influenced by antibiotic administration. Since the concept of antimicrobial prophylaxis has emerged, several workers have searched for optimal antimicrobial drugs, their routes, and the timing of their administration, with the ultimate goal of achieving zero sepsis. The use of preoperative systemic antibiotics has brought down the incidence of wound infection considerably.
Aims and Objectives: The aim is to identify which drug is the best option for single-dose antibiotic prophylaxis to prevent postoperative wound infection.
Materials and Methods: This is a prospective study. The study was conducted in the surgical ward of J.A. Group of Hospitals, Gwalior, Madhya Pradesh, India, from May 2020 to April 2022. Patients of all sexes and ages were included in the study. Patients were divided into five groups according to a class of antibiotics. The study consisted of a total of 125 patients admitted to the surgical ward. Statistical Package for the Social Sciences–(10 systems) was applied for the study. P<0.05 was considered statistically significant.
Results: A total of 125 patients were studied in five groups, depending on the antibiotics. The A, B, C, and D groups were given only a single dose of antibiotics, while group E was given a full course of antibiotics during preoperative, intraoperative, and postoperative periods. Out of 125 cases, only 5 patients had clinical and bacteriological evidence of wound sepsis in different groups of single-dose antibiotics, and one case in group E had multiple doses of antibiotic given. The wound infection rate in clean patients was 20% in ceftazidine, 12.5% with piperacillin tazobactum and cefoperazone sulbactum, and 21.1% in the multiple dose group. No infection was reported with amoxycillin-clavulanic acid. Staphylococcus, Escherichia Coli, and Klebsiella were the offending agents, and anaerobic infections were not found.
Conclusion: A single dose of antibiotic prevents the suppression of normal, sensitive microbial flora, which is usually seen with multiple doses of antibiotics. In this way, it helps in keeping the patients infection-free without interfering with their naturally inherited immunological status of the patient. |
| first_indexed | 2024-03-09T09:35:50Z |
| format | Article |
| id | doaj.art-6b41b3849da54d6ba8cc2e4fc38ca61a |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-09T09:35:50Z |
| publishDate | 2023-12-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-6b41b3849da54d6ba8cc2e4fc38ca61a2023-12-02T02:01:33ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-12-011412249254https://doi.org/10.3126/ajms.v14i12.57680To study the planned surgical procedure in single-dose antibiotic prophylaxisChandrakala Dutt 0https://orcid.org/0009-0000-3587-307XDutt RD 1https://orcid.org/0009-0000-4875-8476Tarushi Dutt 2https://orcid.org/0009-0004-6932-182XJayendra Arya 3https://orcid.org/0000-0001-5094-8551Associate Professor, Department of Surgery, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India Professor, Department of Pediatrics, Gajra Raja Medical College, Gwalior, Madhya Pradesh, IndiaMedical Officer, Morena, Madhya Pradesh, India Senior Resident, Department of Pediatrics, Gajra Raja Medical College, Gwalior, Madhya Pradesh, India Background: Postoperative wound infection may be due to many causes, of which “microbial contamination” is the factor that is influenced by antibiotic administration. Since the concept of antimicrobial prophylaxis has emerged, several workers have searched for optimal antimicrobial drugs, their routes, and the timing of their administration, with the ultimate goal of achieving zero sepsis. The use of preoperative systemic antibiotics has brought down the incidence of wound infection considerably. Aims and Objectives: The aim is to identify which drug is the best option for single-dose antibiotic prophylaxis to prevent postoperative wound infection. Materials and Methods: This is a prospective study. The study was conducted in the surgical ward of J.A. Group of Hospitals, Gwalior, Madhya Pradesh, India, from May 2020 to April 2022. Patients of all sexes and ages were included in the study. Patients were divided into five groups according to a class of antibiotics. The study consisted of a total of 125 patients admitted to the surgical ward. Statistical Package for the Social Sciences–(10 systems) was applied for the study. P<0.05 was considered statistically significant. Results: A total of 125 patients were studied in five groups, depending on the antibiotics. The A, B, C, and D groups were given only a single dose of antibiotics, while group E was given a full course of antibiotics during preoperative, intraoperative, and postoperative periods. Out of 125 cases, only 5 patients had clinical and bacteriological evidence of wound sepsis in different groups of single-dose antibiotics, and one case in group E had multiple doses of antibiotic given. The wound infection rate in clean patients was 20% in ceftazidine, 12.5% with piperacillin tazobactum and cefoperazone sulbactum, and 21.1% in the multiple dose group. No infection was reported with amoxycillin-clavulanic acid. Staphylococcus, Escherichia Coli, and Klebsiella were the offending agents, and anaerobic infections were not found. Conclusion: A single dose of antibiotic prevents the suppression of normal, sensitive microbial flora, which is usually seen with multiple doses of antibiotics. In this way, it helps in keeping the patients infection-free without interfering with their naturally inherited immunological status of the patient.https://www.nepjol.info/index.php/AJMS/article/view/57680antibiotic prophylaxis; cefoparazone; ceftizidime; piperacillin |
| spellingShingle | Chandrakala Dutt Dutt RD Tarushi Dutt Jayendra Arya To study the planned surgical procedure in single-dose antibiotic prophylaxis Asian Journal of Medical Sciences antibiotic prophylaxis; cefoparazone; ceftizidime; piperacillin |
| title | To study the planned surgical procedure in single-dose antibiotic prophylaxis |
| title_full | To study the planned surgical procedure in single-dose antibiotic prophylaxis |
| title_fullStr | To study the planned surgical procedure in single-dose antibiotic prophylaxis |
| title_full_unstemmed | To study the planned surgical procedure in single-dose antibiotic prophylaxis |
| title_short | To study the planned surgical procedure in single-dose antibiotic prophylaxis |
| title_sort | to study the planned surgical procedure in single dose antibiotic prophylaxis |
| topic | antibiotic prophylaxis; cefoparazone; ceftizidime; piperacillin |
| url | https://www.nepjol.info/index.php/AJMS/article/view/57680 |
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