Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms
For decades, vaccines have played a significant role in protecting public and personal health against infectious diseases and proved their great potential in battling cancers as well. This review focused on the current progress of therapeutic subunit vaccines for cancer immunotherapy. Antigens and a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/7/1448 |
| _version_ | 1797416442778353664 |
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| author | Neftali Ortega Alarcon Maddy Jaramillo Heidi M. Mansour Bo Sun |
| author_facet | Neftali Ortega Alarcon Maddy Jaramillo Heidi M. Mansour Bo Sun |
| author_sort | Neftali Ortega Alarcon |
| collection | DOAJ |
| description | For decades, vaccines have played a significant role in protecting public and personal health against infectious diseases and proved their great potential in battling cancers as well. This review focused on the current progress of therapeutic subunit vaccines for cancer immunotherapy. Antigens and adjuvants are key components of vaccine formulations. We summarized several classes of tumor antigens and bioinformatic approaches of identification of tumor neoantigens. Pattern recognition receptor (PRR)-targeting adjuvants and their targeted delivery platforms have been extensively discussed. In addition, we emphasized the interplay between multiple adjuvants and their combined delivery for cancer immunotherapy. |
| first_indexed | 2024-03-09T06:04:22Z |
| format | Article |
| id | doaj.art-6b41f113ce454f9cbdb0df910665a782 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T06:04:22Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-6b41f113ce454f9cbdb0df910665a7822023-12-03T12:06:15ZengMDPI AGPharmaceutics1999-49232022-07-01147144810.3390/pharmaceutics14071448Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery PlatformsNeftali Ortega Alarcon0Maddy Jaramillo1Heidi M. Mansour2Bo Sun3Skaggs Pharmaceutical Sciences Center, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USASkaggs Pharmaceutical Sciences Center, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USASkaggs Pharmaceutical Sciences Center, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USASkaggs Pharmaceutical Sciences Center, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USAFor decades, vaccines have played a significant role in protecting public and personal health against infectious diseases and proved their great potential in battling cancers as well. This review focused on the current progress of therapeutic subunit vaccines for cancer immunotherapy. Antigens and adjuvants are key components of vaccine formulations. We summarized several classes of tumor antigens and bioinformatic approaches of identification of tumor neoantigens. Pattern recognition receptor (PRR)-targeting adjuvants and their targeted delivery platforms have been extensively discussed. In addition, we emphasized the interplay between multiple adjuvants and their combined delivery for cancer immunotherapy.https://www.mdpi.com/1999-4923/14/7/1448therapeutic vaccinetumor antigensadjuvantsdelivery systemscombination therapies |
| spellingShingle | Neftali Ortega Alarcon Maddy Jaramillo Heidi M. Mansour Bo Sun Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms Pharmaceutics therapeutic vaccine tumor antigens adjuvants delivery systems combination therapies |
| title | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
| title_full | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
| title_fullStr | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
| title_full_unstemmed | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
| title_short | Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms |
| title_sort | therapeutic cancer vaccines antigen discovery and adjuvant delivery platforms |
| topic | therapeutic vaccine tumor antigens adjuvants delivery systems combination therapies |
| url | https://www.mdpi.com/1999-4923/14/7/1448 |
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