Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds
Cellular therapies for burn wound healing, including the administration of mesenchymal stem or stromal cells (MSCs), have shown promising results. This review aims to provide an overview of the current administration methods in preclinical and clinical studies of bone-marrow-, adipose-tissue-, and u...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | European Burn Journal |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-1991/3/4/43 |
| _version_ | 1827760193928167424 |
|---|---|
| author | Astrid Bjørke Jenssen Samih Mohamed-Ahmed Esko Kankuri Ragnvald Ljones Brekke Anne Berit Guttormsen Bjørn Tore Gjertsen Kamal Mustafa Stian Kreken Almeland |
| author_facet | Astrid Bjørke Jenssen Samih Mohamed-Ahmed Esko Kankuri Ragnvald Ljones Brekke Anne Berit Guttormsen Bjørn Tore Gjertsen Kamal Mustafa Stian Kreken Almeland |
| author_sort | Astrid Bjørke Jenssen |
| collection | DOAJ |
| description | Cellular therapies for burn wound healing, including the administration of mesenchymal stem or stromal cells (MSCs), have shown promising results. This review aims to provide an overview of the current administration methods in preclinical and clinical studies of bone-marrow-, adipose-tissue-, and umbilical-cord-derived MSCs for treating burn wounds. Relevant studies were identified through a literature search in PubMed and Embase and subjected to inclusion and exclusion criteria for eligibility. Additional relevant studies were identified through a manual search of reference lists. A total of sixty-nine studies were included in this review. Of the included studies, only five had clinical data from patients, one was a prospective case–control, three were case reports, and one was a case series. Administration methods used were local injection (41% in preclinical and 40% in clinical studies), cell-seeded scaffolds (35% and 20%), topical application (17% and 60%), and systemic injection (1% and 0%). There was great heterogeneity between the studies regarding experimental models, administration methods, and cell dosages. Local injection was the most common administration method in animal studies, while topical application was used in most clinical reports. The best delivery method of MSCs in burn wounds is yet to be identified. Although the potential of MSC treatment for burn wounds is promising, future research should focus on examining the effect and scalability of such therapy in clinical trials. |
| first_indexed | 2024-03-11T09:48:08Z |
| format | Article |
| id | doaj.art-6b422b30f26b4169b24579c301fdab89 |
| institution | Directory Open Access Journal |
| issn | 2673-1991 |
| language | English |
| last_indexed | 2024-03-11T09:48:08Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | European Burn Journal |
| spelling | doaj.art-6b422b30f26b4169b24579c301fdab892023-11-16T16:26:53ZengMDPI AGEuropean Burn Journal2673-19912022-11-013449351610.3390/ebj3040043Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn WoundsAstrid Bjørke Jenssen0Samih Mohamed-Ahmed1Esko Kankuri2Ragnvald Ljones Brekke3Anne Berit Guttormsen4Bjørn Tore Gjertsen5Kamal Mustafa6Stian Kreken Almeland7Norwegian National Burn Center, Department of Plastic, Hand, and Reconstructive Surgery, Haukeland University Hospital, 5021 Bergen, NorwayCenter for Translational Oral Research (TOR), Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5020 Bergen, NorwayDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, FinlandNorwegian National Burn Center, Department of Plastic, Hand, and Reconstructive Surgery, Haukeland University Hospital, 5021 Bergen, NorwayDepartment of Clinical Medicine, Faculty of Medicine, University of Bergen, 5020 Bergen, NorwayCentre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, 5020 Bergen, NorwayCenter for Translational Oral Research (TOR), Tissue Engineering Group, Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5020 Bergen, NorwayNorwegian National Burn Center, Department of Plastic, Hand, and Reconstructive Surgery, Haukeland University Hospital, 5021 Bergen, NorwayCellular therapies for burn wound healing, including the administration of mesenchymal stem or stromal cells (MSCs), have shown promising results. This review aims to provide an overview of the current administration methods in preclinical and clinical studies of bone-marrow-, adipose-tissue-, and umbilical-cord-derived MSCs for treating burn wounds. Relevant studies were identified through a literature search in PubMed and Embase and subjected to inclusion and exclusion criteria for eligibility. Additional relevant studies were identified through a manual search of reference lists. A total of sixty-nine studies were included in this review. Of the included studies, only five had clinical data from patients, one was a prospective case–control, three were case reports, and one was a case series. Administration methods used were local injection (41% in preclinical and 40% in clinical studies), cell-seeded scaffolds (35% and 20%), topical application (17% and 60%), and systemic injection (1% and 0%). There was great heterogeneity between the studies regarding experimental models, administration methods, and cell dosages. Local injection was the most common administration method in animal studies, while topical application was used in most clinical reports. The best delivery method of MSCs in burn wounds is yet to be identified. Although the potential of MSC treatment for burn wounds is promising, future research should focus on examining the effect and scalability of such therapy in clinical trials.https://www.mdpi.com/2673-1991/3/4/43stem cellsmesenchymal stromal cellsmesenchymal stem cellsburnswound healingcell delivery |
| spellingShingle | Astrid Bjørke Jenssen Samih Mohamed-Ahmed Esko Kankuri Ragnvald Ljones Brekke Anne Berit Guttormsen Bjørn Tore Gjertsen Kamal Mustafa Stian Kreken Almeland Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds European Burn Journal stem cells mesenchymal stromal cells mesenchymal stem cells burns wound healing cell delivery |
| title | Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds |
| title_full | Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds |
| title_fullStr | Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds |
| title_full_unstemmed | Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds |
| title_short | Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds |
| title_sort | administration methods of mesenchymal stem cells in the treatment of burn wounds |
| topic | stem cells mesenchymal stromal cells mesenchymal stem cells burns wound healing cell delivery |
| url | https://www.mdpi.com/2673-1991/3/4/43 |
| work_keys_str_mv | AT astridbjørkejenssen administrationmethodsofmesenchymalstemcellsinthetreatmentofburnwounds AT samihmohamedahmed administrationmethodsofmesenchymalstemcellsinthetreatmentofburnwounds AT eskokankuri administrationmethodsofmesenchymalstemcellsinthetreatmentofburnwounds AT ragnvaldljonesbrekke administrationmethodsofmesenchymalstemcellsinthetreatmentofburnwounds AT anneberitguttormsen administrationmethodsofmesenchymalstemcellsinthetreatmentofburnwounds AT bjørntoregjertsen administrationmethodsofmesenchymalstemcellsinthetreatmentofburnwounds AT kamalmustafa administrationmethodsofmesenchymalstemcellsinthetreatmentofburnwounds AT stiankrekenalmeland administrationmethodsofmesenchymalstemcellsinthetreatmentofburnwounds |