All for one and FOSL1 for all: FOSL1 at the crossroads of lung and pancreatic cancer driven by mutant KRAS

All for one and FOSL1 for all: FOSL1 at the crossroads of lung and pancreatic cancer driven by mutant KRAS

KRAS proto-oncogene, GTPase (KRAS) remains refractory to current therapies. We devised an integrative cross-tumor approach to expose common core elements up-regulated in mutant KRAS cancers that could provide new treatment opportunities. This approach identified FOSL1 (Fos-like antigen 1) as a clini...

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Bibliographic Details
Main Authors: Adrian Vallejo, Karmele Valencia, Silvestre Vicent
Format: Article
Language:English
Published: Taylor & Francis Group 2017-05-01
Series:Molecular & Cellular Oncology
Subjects:
fosl1
gene signature
kras oncogene
lung cancer
mouse genetics
pancreatic cancer
pharmacological inhibitors
Online Access:http://dx.doi.org/10.1080/23723556.2017.1314239

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