Tumor angiogenesis in colorectal cancer, correlation with tumor extension and invasion
Tumor angiogenesis shown by Microvessel Count (MVC) or Microvessel Density (MVD), is assessed by several studies as prognostic factor in some types of tumors, and also in colorectal carcinoma. This article is payed to correlation between clincopathologic factors and tumor angiogenesis. In this study...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Tehran University of Medical Sciences
2001-09-01
|
| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5571.pdf&manuscript_id=5571 |
| _version_ | 1818379363707518976 |
|---|---|
| author | Javadi P Haeri H |
| author_facet | Javadi P Haeri H |
| author_sort | Javadi P |
| collection | DOAJ |
| description | Tumor angiogenesis shown by Microvessel Count (MVC) or Microvessel Density (MVD), is assessed by several studies as prognostic factor in some types of tumors, and also in colorectal carcinoma. This article is payed to correlation between clincopathologic factors and tumor angiogenesis. In this study, immunohistochemical techniques are used for vascular evaluation in specimens from twenty-nine colorectal carcinoma, and stained for Factor VIII-Related Antigen (F8RA) by using monoclonal antibody. Uni and multivariate analysis disclosed that total MVC was higher in tumor [76.3±33 (×100=2.5 mm²/field) and 29.8±11 (×200=0.785 mm²/field)] than in normal tissue [37.7±15.8 (×100) and 17.6±7.8 (×200)], (P=0.022, P=0.000009). Microvessel quantification was significantly higher in stage D (115±36.6, ×100 and 26.7±6.4, ×200, P=0.002 and P=0.04). In this study MVD has correlation with vascular invasion (P=0.024, ×100 and P=0.007, ×200), the mean tumor vessel count although was increased with clinicophatologic findings such as age<60 years, male, right colon involvement, infiltrating type, mucinous carcinoma, transmural penetration, grade III, lymphatic and perineural invasion, but was not statistically significant. Lymph node and hematogenous metastasis and size of tumor also, was not important. As a conclusion, MVD was increased in tumor and has shown correlation with metastasis, and vascular invasion. Resulting angiogenesis increase risk of metastasis. |
| first_indexed | 2024-12-14T02:01:36Z |
| format | Article |
| id | doaj.art-6b42c54319ac43848e27435616509b3f |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-14T02:01:36Z |
| publishDate | 2001-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-6b42c54319ac43848e27435616509b3f2022-12-21T23:20:59ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222001-09-015945056Tumor angiogenesis in colorectal cancer, correlation with tumor extension and invasionJavadi PHaeri HTumor angiogenesis shown by Microvessel Count (MVC) or Microvessel Density (MVD), is assessed by several studies as prognostic factor in some types of tumors, and also in colorectal carcinoma. This article is payed to correlation between clincopathologic factors and tumor angiogenesis. In this study, immunohistochemical techniques are used for vascular evaluation in specimens from twenty-nine colorectal carcinoma, and stained for Factor VIII-Related Antigen (F8RA) by using monoclonal antibody. Uni and multivariate analysis disclosed that total MVC was higher in tumor [76.3±33 (×100=2.5 mm²/field) and 29.8±11 (×200=0.785 mm²/field)] than in normal tissue [37.7±15.8 (×100) and 17.6±7.8 (×200)], (P=0.022, P=0.000009). Microvessel quantification was significantly higher in stage D (115±36.6, ×100 and 26.7±6.4, ×200, P=0.002 and P=0.04). In this study MVD has correlation with vascular invasion (P=0.024, ×100 and P=0.007, ×200), the mean tumor vessel count although was increased with clinicophatologic findings such as age<60 years, male, right colon involvement, infiltrating type, mucinous carcinoma, transmural penetration, grade III, lymphatic and perineural invasion, but was not statistically significant. Lymph node and hematogenous metastasis and size of tumor also, was not important. As a conclusion, MVD was increased in tumor and has shown correlation with metastasis, and vascular invasion. Resulting angiogenesis increase risk of metastasis.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5571.pdf&manuscript_id=5571Microvessel densityMicrovessel countTumor angiogenesisFactor VIII related antigenColorectal cancerDuke stage |
| spellingShingle | Javadi P Haeri H Tumor angiogenesis in colorectal cancer, correlation with tumor extension and invasion Tehran University Medical Journal Microvessel density Microvessel count Tumor angiogenesis Factor VIII related antigen Colorectal cancer Duke stage |
| title | Tumor angiogenesis in colorectal cancer, correlation with tumor extension and invasion |
| title_full | Tumor angiogenesis in colorectal cancer, correlation with tumor extension and invasion |
| title_fullStr | Tumor angiogenesis in colorectal cancer, correlation with tumor extension and invasion |
| title_full_unstemmed | Tumor angiogenesis in colorectal cancer, correlation with tumor extension and invasion |
| title_short | Tumor angiogenesis in colorectal cancer, correlation with tumor extension and invasion |
| title_sort | tumor angiogenesis in colorectal cancer correlation with tumor extension and invasion |
| topic | Microvessel density Microvessel count Tumor angiogenesis Factor VIII related antigen Colorectal cancer Duke stage |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5571.pdf&manuscript_id=5571 |
| work_keys_str_mv | AT javadip tumorangiogenesisincolorectalcancercorrelationwithtumorextensionandinvasion AT haerih tumorangiogenesisincolorectalcancercorrelationwithtumorextensionandinvasion |