PARP inhibitors in gastric cancer: beacon of hope
Abstract Defects in the DNA damage response (DDR) can lead to genome instability, producing mutations or aberrations that promote the development and progression of cancer. But it also confers such cells vulnerable to cell death when they inhibit DNA damage repair. Poly (ADP-ribose) polymerase (PARP...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-021-02005-6 |
| _version_ | 1818639921901993984 |
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| author | Yali Wang Kun Zheng Yongbiao Huang Hua Xiong Jinfang Su Rui Chen Yanmei Zou |
| author_facet | Yali Wang Kun Zheng Yongbiao Huang Hua Xiong Jinfang Su Rui Chen Yanmei Zou |
| author_sort | Yali Wang |
| collection | DOAJ |
| description | Abstract Defects in the DNA damage response (DDR) can lead to genome instability, producing mutations or aberrations that promote the development and progression of cancer. But it also confers such cells vulnerable to cell death when they inhibit DNA damage repair. Poly (ADP-ribose) polymerase (PARP) plays a central role in many cellular processes, including DNA repair, replication, and transcription. PARP induces the occurrence of poly (ADP-ribosylation) (PARylation) when DNA single strand breaks (SSB) occur. PARP and various proteins can interact directly or indirectly through PARylation to regulate DNA repair. Inhibitors that directly target PARP have been found to block the SSB repair pathway, triggering homologous recombination deficiency (HRD) cancers to form synthetic lethal concepts that represent an anticancer strategy. It has therefore been investigated in many cancer types for more effective anti-cancer strategies, including gastric cancer (GC). This review describes the antitumor mechanisms of PARP inhibitors (PARPis), and the preclinical and clinical progress of PARPis as monotherapy and combination therapy in GC. |
| first_indexed | 2024-12-16T23:03:04Z |
| format | Article |
| id | doaj.art-6b436e01fc8741738adf02d86032ce81 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-16T23:03:04Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-6b436e01fc8741738adf02d86032ce812022-12-21T22:12:40ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662021-06-0140111310.1186/s13046-021-02005-6PARP inhibitors in gastric cancer: beacon of hopeYali Wang0Kun Zheng1Yongbiao Huang2Hua Xiong3Jinfang Su4Rui Chen5Yanmei Zou6Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Defects in the DNA damage response (DDR) can lead to genome instability, producing mutations or aberrations that promote the development and progression of cancer. But it also confers such cells vulnerable to cell death when they inhibit DNA damage repair. Poly (ADP-ribose) polymerase (PARP) plays a central role in many cellular processes, including DNA repair, replication, and transcription. PARP induces the occurrence of poly (ADP-ribosylation) (PARylation) when DNA single strand breaks (SSB) occur. PARP and various proteins can interact directly or indirectly through PARylation to regulate DNA repair. Inhibitors that directly target PARP have been found to block the SSB repair pathway, triggering homologous recombination deficiency (HRD) cancers to form synthetic lethal concepts that represent an anticancer strategy. It has therefore been investigated in many cancer types for more effective anti-cancer strategies, including gastric cancer (GC). This review describes the antitumor mechanisms of PARP inhibitors (PARPis), and the preclinical and clinical progress of PARPis as monotherapy and combination therapy in GC.https://doi.org/10.1186/s13046-021-02005-6PARP inhibitorGastric cancerDNA damage responseCancer treatment |
| spellingShingle | Yali Wang Kun Zheng Yongbiao Huang Hua Xiong Jinfang Su Rui Chen Yanmei Zou PARP inhibitors in gastric cancer: beacon of hope Journal of Experimental & Clinical Cancer Research PARP inhibitor Gastric cancer DNA damage response Cancer treatment |
| title | PARP inhibitors in gastric cancer: beacon of hope |
| title_full | PARP inhibitors in gastric cancer: beacon of hope |
| title_fullStr | PARP inhibitors in gastric cancer: beacon of hope |
| title_full_unstemmed | PARP inhibitors in gastric cancer: beacon of hope |
| title_short | PARP inhibitors in gastric cancer: beacon of hope |
| title_sort | parp inhibitors in gastric cancer beacon of hope |
| topic | PARP inhibitor Gastric cancer DNA damage response Cancer treatment |
| url | https://doi.org/10.1186/s13046-021-02005-6 |
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