Increased plasma XOR activity induced by NAFLD/NASH and its possible involvement in vascular neointimal proliferation

Increased plasma XOR activity induced by NAFLD/NASH and its possible involvement in vascular neointimal proliferation

Xanthine oxidoreductase (XOR) is an enzyme that catalyzes hypoxanthine to xanthine and xanthine to uric acid, respectively. However, the underlying mechanisms of increased plasma XOR and its pathological roles in systemic diseases, such as atherosclerosis, are not fully understood. In this study, we...

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Bibliographic Details
Main Authors: Yusuke Kawachi, Yuya Fujishima, Hitoshi Nishizawa, Takashi Nakamura, Seigo Akari, Takayo Murase, Takuro Saito, Yasuhiro Miyazaki, Hirofumi Nagao, Shiro Fukuda, Shunbun Kita, Naoto Katakami, Yuichiro Doki, Norikazu Maeda, Iichiro Shimomura
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-09-01
Series:JCI Insight
Subjects:
Hepatology
Metabolism
Online Access:https://doi.org/10.1172/jci.insight.144762

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