Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death
Energy transfer to ground state triplet molecular oxygen results in the generation of singlet molecular oxygen (<sup>1</sup>O<sub>2</sub>), which has potent oxidizing ability. Irradiation of light, notably ultraviolet A, to a photosensitizing molecule results in the generatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/10/4085 |
| _version_ | 1797598919439417344 |
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| author | Junichi Fujii Yuya Soma Yumi Matsuda |
| author_facet | Junichi Fujii Yuya Soma Yumi Matsuda |
| author_sort | Junichi Fujii |
| collection | DOAJ |
| description | Energy transfer to ground state triplet molecular oxygen results in the generation of singlet molecular oxygen (<sup>1</sup>O<sub>2</sub>), which has potent oxidizing ability. Irradiation of light, notably ultraviolet A, to a photosensitizing molecule results in the generation of <sup>1</sup>O<sub>2</sub>, which is thought to play a role in causing skin damage and aging. It should also be noted that <sup>1</sup>O<sub>2</sub> is a dominant tumoricidal component that is generated during the photodynamic therapy (PDT). While type II photodynamic action generates not only <sup>1</sup>O<sub>2</sub> but also other reactive species, endoperoxides release pure <sup>1</sup>O<sub>2</sub> upon mild exposure to heat and, hence, are considered to be beneficial compounds for research purposes. Concerning target molecules, <sup>1</sup>O<sub>2</sub> preferentially reacts with unsaturated fatty acids to produce lipid peroxidation. Enzymes that contain a reactive cysteine group at the catalytic center are vulnerable to <sup>1</sup>O<sub>2</sub> exposure. Guanine base in nucleic acids is also susceptible to oxidative modification, and cells carrying DNA with oxidized guanine units may experience mutations. Since <sup>1</sup>O<sub>2</sub> is produced in various physiological reactions in addition to photodynamic reactions, overcoming technical challenges related to its detection and methods used for its generation would allow its potential functions in biological systems to be better understood. |
| first_indexed | 2024-03-11T03:27:24Z |
| format | Article |
| id | doaj.art-6b45d9d572bf464cb56d51d0c430f7a8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:27:24Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6b45d9d572bf464cb56d51d0c430f7a82023-11-18T02:39:01ZengMDPI AGMolecules1420-30492023-05-012810408510.3390/molecules28104085Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and DeathJunichi Fujii0Yuya Soma1Yumi Matsuda2Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata 990-9585, JapanGraduate School of Nursing, Yamagata University Faculty of Medicine, Yamagata 990-9585, JapanGraduate School of Nursing, Yamagata University Faculty of Medicine, Yamagata 990-9585, JapanEnergy transfer to ground state triplet molecular oxygen results in the generation of singlet molecular oxygen (<sup>1</sup>O<sub>2</sub>), which has potent oxidizing ability. Irradiation of light, notably ultraviolet A, to a photosensitizing molecule results in the generation of <sup>1</sup>O<sub>2</sub>, which is thought to play a role in causing skin damage and aging. It should also be noted that <sup>1</sup>O<sub>2</sub> is a dominant tumoricidal component that is generated during the photodynamic therapy (PDT). While type II photodynamic action generates not only <sup>1</sup>O<sub>2</sub> but also other reactive species, endoperoxides release pure <sup>1</sup>O<sub>2</sub> upon mild exposure to heat and, hence, are considered to be beneficial compounds for research purposes. Concerning target molecules, <sup>1</sup>O<sub>2</sub> preferentially reacts with unsaturated fatty acids to produce lipid peroxidation. Enzymes that contain a reactive cysteine group at the catalytic center are vulnerable to <sup>1</sup>O<sub>2</sub> exposure. Guanine base in nucleic acids is also susceptible to oxidative modification, and cells carrying DNA with oxidized guanine units may experience mutations. Since <sup>1</sup>O<sub>2</sub> is produced in various physiological reactions in addition to photodynamic reactions, overcoming technical challenges related to its detection and methods used for its generation would allow its potential functions in biological systems to be better understood.https://www.mdpi.com/1420-3049/28/10/4085photodynamic therapyultravioletendoperoxideslipid peroxidationapoptosisferroptosis |
| spellingShingle | Junichi Fujii Yuya Soma Yumi Matsuda Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death Molecules photodynamic therapy ultraviolet endoperoxides lipid peroxidation apoptosis ferroptosis |
| title | Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death |
| title_full | Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death |
| title_fullStr | Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death |
| title_full_unstemmed | Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death |
| title_short | Biological Action of Singlet Molecular Oxygen from the Standpoint of Cell Signaling, Injury and Death |
| title_sort | biological action of singlet molecular oxygen from the standpoint of cell signaling injury and death |
| topic | photodynamic therapy ultraviolet endoperoxides lipid peroxidation apoptosis ferroptosis |
| url | https://www.mdpi.com/1420-3049/28/10/4085 |
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