Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors

Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors

The screened compound DYT-1 from our in-house library was taken as a lead (inhibiting tubulin polymerisation: IC50=25.6 µM, anti-angiogenesis in Zebrafish: IC50=38.4 µM, anti-proliferation against K562 and Jurkat: IC50=6.2 and 7.9 µM, respectively). Further investigation of medicinal chemistry condi...

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Bibliographic Details
Main Authors:	Yongfang Yao, Tao Huang, Yuyang Wang, Longfei Wang, Siqi Feng, Weyland Cheng, Longhua Yang, Yongtao Duan
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2022-12-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	leukaemia anti-angiogenesis tubulin zebrafish
Online Access:	http://dx.doi.org/10.1080/14756366.2022.2032688

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