Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation

Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation

Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme oxygenase-1 (HO-1), exerts a central role in cellular protection. The substrate, heme, is a potent pro-oxidant that can accelera...

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Bibliographic Details
Main Author: Stefan W. Ryter
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
apoptosis
autophagy
carbon monoxide
cell death
ferroptosis
heme oxygenase
Online Access:https://www.mdpi.com/2073-4409/10/3/515

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