Clinical Significance of Preoperative Inflammatory Markers in Prediction of Prognosis in Node-Negative Colon Cancer: Correlation between Neutrophil-to-Lymphocyte Ratio and Poorly Differentiated Clusters
Although stage I and II colon cancers (CC) generally show a very good prognosis, a small proportion of these patients dies from recurrent disease. The identification of high-risk patients, who may benefit from adjuvant chemotherapy, becomes therefore essential. We retrospectively evaluated 107 cases...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/2227-9059/9/1/94 |
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| author | Giulia Turri Valeria Barresi Alessandro Valdegamberi Gabriele Gecchele Cristian Conti Serena Ammendola Alfredo Guglielmi Aldo Scarpa Corrado Pedrazzani |
| author_facet | Giulia Turri Valeria Barresi Alessandro Valdegamberi Gabriele Gecchele Cristian Conti Serena Ammendola Alfredo Guglielmi Aldo Scarpa Corrado Pedrazzani |
| author_sort | Giulia Turri |
| collection | DOAJ |
| description | Although stage I and II colon cancers (CC) generally show a very good prognosis, a small proportion of these patients dies from recurrent disease. The identification of high-risk patients, who may benefit from adjuvant chemotherapy, becomes therefore essential. We retrospectively evaluated 107 cases of stage I (<i>n</i> = 28, 26.2%) and II (<i>n</i> = 79, 73.8%) CC for correlations among preoperative inflammatory markers, histopathological factors and long-term prognosis. A neutrophil-to-lymphocyte ratio greater than 3 (H-NLR) and a platelet-to-lymphocyte ratio greater than 150 (H-PLR) were significantly associated with the presence of poorly differentiated clusters (PDC) (<i>p</i> = 0.007 and <i>p</i> = 0.039, respectively). In addition, H-NLR and PDC proved to be significant and independent survival prognosticators for overall survival (OS; <i>p</i> = 0.007 and <i>p</i> < 0.001, respectively), while PDC was the only significant prognostic factor for cancer-specific survival (CSS; <i>p</i> < 0.001,). Finally, the combination of H-NLR and PDC allowed an optimal stratification of OS and CSS in our cohort, suggesting a potential role in clinical practice for the identification of high-risk patients with stage I and II CC. |
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| issn | 2227-9059 |
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| spelling | doaj.art-6b4b8e60aa564bc68eec1db8c4cd61ee2023-12-03T13:50:08ZengMDPI AGBiomedicines2227-90592021-01-01919410.3390/biomedicines9010094Clinical Significance of Preoperative Inflammatory Markers in Prediction of Prognosis in Node-Negative Colon Cancer: Correlation between Neutrophil-to-Lymphocyte Ratio and Poorly Differentiated ClustersGiulia Turri0Valeria Barresi1Alessandro Valdegamberi2Gabriele Gecchele3Cristian Conti4Serena Ammendola5Alfredo Guglielmi6Aldo Scarpa7Corrado Pedrazzani8Unit of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37134 Verona, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, 37134 Verona, ItalyUnit of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37134 Verona, ItalyUnit of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37134 Verona, ItalyUnit of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37134 Verona, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, 37134 Verona, ItalyUnit of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37134 Verona, ItalyDepartment of Diagnostics and Public Health, Section of Pathology, University of Verona, 37134 Verona, ItalyUnit of General and Hepatobiliary Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37134 Verona, ItalyAlthough stage I and II colon cancers (CC) generally show a very good prognosis, a small proportion of these patients dies from recurrent disease. The identification of high-risk patients, who may benefit from adjuvant chemotherapy, becomes therefore essential. We retrospectively evaluated 107 cases of stage I (<i>n</i> = 28, 26.2%) and II (<i>n</i> = 79, 73.8%) CC for correlations among preoperative inflammatory markers, histopathological factors and long-term prognosis. A neutrophil-to-lymphocyte ratio greater than 3 (H-NLR) and a platelet-to-lymphocyte ratio greater than 150 (H-PLR) were significantly associated with the presence of poorly differentiated clusters (PDC) (<i>p</i> = 0.007 and <i>p</i> = 0.039, respectively). In addition, H-NLR and PDC proved to be significant and independent survival prognosticators for overall survival (OS; <i>p</i> = 0.007 and <i>p</i> < 0.001, respectively), while PDC was the only significant prognostic factor for cancer-specific survival (CSS; <i>p</i> < 0.001,). Finally, the combination of H-NLR and PDC allowed an optimal stratification of OS and CSS in our cohort, suggesting a potential role in clinical practice for the identification of high-risk patients with stage I and II CC.https://www.mdpi.com/2227-9059/9/1/94colon cancerpoorly differentiated clustersprognostic factorsinflammatory markershistopathological markersimmune system |
| spellingShingle | Giulia Turri Valeria Barresi Alessandro Valdegamberi Gabriele Gecchele Cristian Conti Serena Ammendola Alfredo Guglielmi Aldo Scarpa Corrado Pedrazzani Clinical Significance of Preoperative Inflammatory Markers in Prediction of Prognosis in Node-Negative Colon Cancer: Correlation between Neutrophil-to-Lymphocyte Ratio and Poorly Differentiated Clusters Biomedicines colon cancer poorly differentiated clusters prognostic factors inflammatory markers histopathological markers immune system |
| title | Clinical Significance of Preoperative Inflammatory Markers in Prediction of Prognosis in Node-Negative Colon Cancer: Correlation between Neutrophil-to-Lymphocyte Ratio and Poorly Differentiated Clusters |
| title_full | Clinical Significance of Preoperative Inflammatory Markers in Prediction of Prognosis in Node-Negative Colon Cancer: Correlation between Neutrophil-to-Lymphocyte Ratio and Poorly Differentiated Clusters |
| title_fullStr | Clinical Significance of Preoperative Inflammatory Markers in Prediction of Prognosis in Node-Negative Colon Cancer: Correlation between Neutrophil-to-Lymphocyte Ratio and Poorly Differentiated Clusters |
| title_full_unstemmed | Clinical Significance of Preoperative Inflammatory Markers in Prediction of Prognosis in Node-Negative Colon Cancer: Correlation between Neutrophil-to-Lymphocyte Ratio and Poorly Differentiated Clusters |
| title_short | Clinical Significance of Preoperative Inflammatory Markers in Prediction of Prognosis in Node-Negative Colon Cancer: Correlation between Neutrophil-to-Lymphocyte Ratio and Poorly Differentiated Clusters |
| title_sort | clinical significance of preoperative inflammatory markers in prediction of prognosis in node negative colon cancer correlation between neutrophil to lymphocyte ratio and poorly differentiated clusters |
| topic | colon cancer poorly differentiated clusters prognostic factors inflammatory markers histopathological markers immune system |
| url | https://www.mdpi.com/2227-9059/9/1/94 |
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