Preparation of 2'-13C-L-Histidine Starting from 13C-Thiocyanate: Synthetic Access to Any Site-Directed Stable Isotope Enriched L-Histidine

Preparation of 2'-13C-L-Histidine Starting from 13C-Thiocyanate: Synthetic Access to Any Site-Directed Stable Isotope Enriched L-Histidine

1-Benzyl-2-(methylthio)-imidazole-5-ketone is obtained in a few simple steps starting from thiocyanate and glycine amide (glycin). Subsequent treatment with diethyl phosphorocyanidate and functional group manipulations gives 1-benzyl-5-chloromethyl-imidazolium chloride. This compound is converted un...

Full description

Bibliographic Details
Main Authors: Sarra Talab, Kamal Khalifa Taha, Johan Lugtenburg
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Molecules
Subjects:
1-benzyl-2-(methylthio)-5-imidazole carbonitrile
ethyl-1-benzyl-5-imidazol-carboxylate
N-diphenylmethylene glycine tert-butyl ester
O’Donnell method
Online Access:http://www.mdpi.com/1420-3049/19/1/1023

Internet

http://www.mdpi.com/1420-3049/19/1/1023

Similar Items