Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila
Mechanosensory neurons located across the body surface respond to tactile stimuli and elicit diverse behavioral responses, from relatively simple stimulus location-aimed movements to complex movement sequences. How mechanosensory neurons and their postsynaptic circuits influence such diverse behavio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2024-04-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/87602 |
| _version_ | 1797201729488420864 |
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| author | Katharina Eichler Stefanie Hampel Adrián Alejandro-García Steven A Calle-Schuler Alexis Santana-Cruz Lucia Kmecova Jonathan M Blagburn Eric D Hoopfer Andrew M Seeds |
| author_facet | Katharina Eichler Stefanie Hampel Adrián Alejandro-García Steven A Calle-Schuler Alexis Santana-Cruz Lucia Kmecova Jonathan M Blagburn Eric D Hoopfer Andrew M Seeds |
| author_sort | Katharina Eichler |
| collection | DOAJ |
| description | Mechanosensory neurons located across the body surface respond to tactile stimuli and elicit diverse behavioral responses, from relatively simple stimulus location-aimed movements to complex movement sequences. How mechanosensory neurons and their postsynaptic circuits influence such diverse behaviors remains unclear. We previously discovered that Drosophila perform a body location-prioritized grooming sequence when mechanosensory neurons at different locations on the head and body are simultaneously stimulated by dust (Hampel et al., 2017; Seeds et al., 2014). Here, we identify nearly all mechanosensory neurons on the Drosophila head that individually elicit aimed grooming of specific head locations, while collectively eliciting a whole head grooming sequence. Different tracing methods were used to reconstruct the projections of these neurons from different locations on the head to their distinct arborizations in the brain. This provides the first synaptic resolution somatotopic map of a head, and defines the parallel-projecting mechanosensory pathways that elicit head grooming. |
| first_indexed | 2024-04-24T07:52:10Z |
| format | Article |
| id | doaj.art-6b4da80def3c429a8e7f1141d32972a7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-24T07:52:10Z |
| publishDate | 2024-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-6b4da80def3c429a8e7f1141d32972a72024-04-18T10:32:17ZengeLife Sciences Publications LtdeLife2050-084X2024-04-011210.7554/eLife.87602Somatotopic organization among parallel sensory pathways that promote a grooming sequence in DrosophilaKatharina Eichler0https://orcid.org/0000-0002-7833-8621Stefanie Hampel1https://orcid.org/0000-0001-8287-549XAdrián Alejandro-García2Steven A Calle-Schuler3https://orcid.org/0000-0003-1304-585XAlexis Santana-Cruz4https://orcid.org/0000-0002-8162-8072Lucia Kmecova5Jonathan M Blagburn6https://orcid.org/0000-0002-7681-2764Eric D Hoopfer7Andrew M Seeds8https://orcid.org/0000-0002-4932-6496Institute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto RicoInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto RicoInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto RicoInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto RicoInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto RicoInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto RicoInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto RicoNeuroscience Program, Carleton College, Northfield, United StatesInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto RicoMechanosensory neurons located across the body surface respond to tactile stimuli and elicit diverse behavioral responses, from relatively simple stimulus location-aimed movements to complex movement sequences. How mechanosensory neurons and their postsynaptic circuits influence such diverse behaviors remains unclear. We previously discovered that Drosophila perform a body location-prioritized grooming sequence when mechanosensory neurons at different locations on the head and body are simultaneously stimulated by dust (Hampel et al., 2017; Seeds et al., 2014). Here, we identify nearly all mechanosensory neurons on the Drosophila head that individually elicit aimed grooming of specific head locations, while collectively eliciting a whole head grooming sequence. Different tracing methods were used to reconstruct the projections of these neurons from different locations on the head to their distinct arborizations in the brain. This provides the first synaptic resolution somatotopic map of a head, and defines the parallel-projecting mechanosensory pathways that elicit head grooming.https://elifesciences.org/articles/87602somatotopic mapgroomingmechanosensorybehavioral sequencescratch reflexneurons |
| spellingShingle | Katharina Eichler Stefanie Hampel Adrián Alejandro-García Steven A Calle-Schuler Alexis Santana-Cruz Lucia Kmecova Jonathan M Blagburn Eric D Hoopfer Andrew M Seeds Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila eLife somatotopic map grooming mechanosensory behavioral sequence scratch reflex neurons |
| title | Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila |
| title_full | Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila |
| title_fullStr | Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila |
| title_full_unstemmed | Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila |
| title_short | Somatotopic organization among parallel sensory pathways that promote a grooming sequence in Drosophila |
| title_sort | somatotopic organization among parallel sensory pathways that promote a grooming sequence in drosophila |
| topic | somatotopic map grooming mechanosensory behavioral sequence scratch reflex neurons |
| url | https://elifesciences.org/articles/87602 |
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